Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 556.00 |
Description | TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity. |
Targets&IC50 | TLR5/flagellin complex:0.85 μM (IC50) |
In vivo | TH1020 was repress the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation.?Based on molecular docking simulation, TH1020 is suggested to compete with flagellin and disrupt its association with TLR5.?TH1020 provides a much-needed molecular probe for studying this important protein-protein interaction and a lead compound for identifying novel therapeutics targeting TLR5. |
Molecular Weight | 453.54 |
Formula | C23H15N7S2 |
CAS No. | 1841460-82-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.5 mM
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TH1020 1841460-82-9 Immunology/Inflammation Microbiology/Virology Antibacterial TLR interaction inhibit Bacterial flagellin Toll-like Receptor (TLR) TLR5 protein-protein TH-1020 TNF-α Inhibitor TH 1020 inhibitor