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Tegoprazan
🥰Excellent
Catalog No. T17030Cas No. 942195-55-3
Tegoprazan is an orally active, highly selective gastric H+/K+-ATPase inhibitor that controls gastric acid secretion and motility, with an IC50 of 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPase in vitro.
Tegoprazan
🥰Excellent
Purity: 98.22%
Catalog No. T17030Cas No. 942195-55-3
Tegoprazan is an orally active, highly selective gastric H+/K+-ATPase inhibitor that controls gastric acid secretion and motility, with an IC50 of 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPase in vitro.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $123 | In Stock | |
| 10 mg | $189 | In Stock | |
| 25 mg | $313 | In Stock | |
| 50 mg | $413 | In Stock | |
| 100 mg | $538 | In Stock | |
| 200 mg | $766 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $135 | In Stock |
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Purity:98.22%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Tegoprazan is an orally active, highly selective gastric H+/K+-ATPase inhibitor that controls gastric acid secretion and motility, with an IC50 of 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPase in vitro. |
| Targets&IC50 | H+, K+-ATPase:0.29-0.52 μM |
| In vitro | METHODS: BMM cells were cultured with Tegoprazan (CJ-12420) (0, 0.0005, 0.001, 0.005, 0.01, 0.05, 0.1, 0.5, 1, 10, 100 and 1000 μg/mL, 24 hours) to investigate its effects on BMM cytotoxicity and nitric oxide (NO) production. RESULTS When the concentration of Tegoprazan was 0.5, 1, 10 and 100 μg/mL, the cell viability exceeded 80%; when the concentration was 1000 μg/mL, the cell viability was less than 80%; 100 μg/mL of Tegoprazan could significantly inhibit NO production in BMM cells. [3] |
| In vivo | METHODS: Tegoprazan (CJ-12420) (3, 10 mg/kg, oral, 5 days) was used to treat pylorus-ligated rats, and the effects of Tegoprazan and esomeprazole on gastric acid secretion in pylorus-ligated rats were observed. RESULTS The gastric fundus pH values ​​of 3 mg/kg Tegoprazan were 4.13 and 4.34, respectively, and the gastric fundus pH values ​​of 10 mg/kg Tegoprazan were 6.86 and 6.63, respectively. Tegoprazan can completely inhibit gastric acid secretion. [3] |
| Molecular Weight | 387.38 |
| Formula | C20H19F2N3O3 |
| Cas No. | 942195-55-3 |
| Smiles | CN(C)C(=O)c1cc(O[C@H]2CCOc3cc(F)cc(F)c23)c2[nH]c(C)nc2c1 |
| Relative Density. | 1.371 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.5 mg/mL (58.08 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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