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Tolazoline

Catalog No. T21447 CAS 59-98-3

Synonyms: Priscol, Priscoline, Pridazole, Divascol, Vasimid, Benzalolin

Tolazoline (Benzalolin), a non-selective competitive α-adrenergic receptor antagonist, is used as a vasodilator to treat spasms of peripheral blood vessels. It has also been used successfully as an antidote to reverse the severe peripheral vasoconstriction as a result of overdose with certain 5-HT2A agonist drugs.

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Tolazoline, CAS 59-98-3

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 97.51%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Priscol, Priscoline, Pridazole, Divascol, Vasimid, Benzalolin
Molecular Weight	160.22
Formula	C10H12N2
CAS No.	59-98-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (343.28 mM)

H2O: Insoluble

References and Literature

1. Casbeer HC, Knych HK. Pharmacokinetics and pharmacodynamic effects of tolazoline following intravenous administration to horses. Vet J. 2013 Jun;196(3):504-9. 2. Yokota S, Hikasa Y, Shimura I, Kusunose S. Effects of imidazoline and nonimidazoline alpha-adrenergic agents, including xylazine, medetomidine, yohimbine, tolazoline, and atipamezole, on aggregation of bovine and equine platelets. Am J Vet Res. 2013 Mar;74(3):395-402. 3. Contreras CD, Ledesma AE, Zinczuk J, Brandán SA. Vibrational study of tolazoline hydrochloride by using FTIR-Raman and DFT calculations. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Sep;79(5):1710-4. 4. Mortenson JA, Robison JA. Tolazoline-induced apnea in mule deer (Odocoileus hemionus). J Zoo Wildl Med. 2011 Mar;42(1):105-7.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library GPCR Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Inhibitor Library Anti-Neurodegenerative Disease Compound Library ReFRAME Related Library FDA-Approved & Pharmacopeia Drug Library Anti-Alzheimer's Disease Compound Library

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tolazoline 59-98-3 GPCR/G Protein Neuroscience Adrenergic Receptor Priscol Priscoline Pridazole Divascol Vasimid NSC 35110 Inhibitor NSC35110 NSC-35110 Imidaline Beta Receptor inhibit Benzalolin inhibitor

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