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Trimethoprim

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Purity:99.88%

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COA HNMR HPLC

Trimethoprim

Catalog No. T1153Cas No. 738-70-5

Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.

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Pack Size	Price	Availability	Quantity
500 mg	$45	In Stock

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Product Introduction

Bioactivity

Description	Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
In vivo	Trimethoprim acts by interfering with the bacterial dihydrofolate reductase, inhibiting the synthesis of tetrahydrofolic acid. This inhibition causes a deficiency in nucleotides essential for bacterial DNA replication, which in some instances leads to cell death due to thymineless death.
Alias	NIH 204, BW 56-72, NSC-106568

Chemical Properties

Molecular Weight	290.32
Formula	C14H18N4O3
Cas No.	738-70-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (189.45 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4445 mL	17.2224 mL	34.4448 mL	172.2238 mL
5 mM	0.6889 mL	3.4445 mL	6.8890 mL	34.4448 mL
10 mM	0.3444 mL	1.7222 mL	3.4445 mL	17.2224 mL
20 mM	0.1722 mL	0.8611 mL	1.7222 mL	8.6112 mL
50 mM	0.0689 mL	0.3444 mL	0.6889 mL	3.4445 mL
100 mM	0.0344 mL	0.1722 mL	0.3444 mL	1.7222 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Trimethoprim

Trimethoprim