Shopping Cart
- Remove All
- Your shopping cart is currently empty
Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $42 | In Stock | |
10 mg | $66 | In Stock | |
25 mg | $132 | In Stock | |
50 mg | $197 | In Stock | |
100 mg | $337 | In Stock | |
200 mg | $497 | In Stock | |
500 mg | $793 | In Stock | |
1 mL x 10 mM (in DMSO) | $46 | In Stock |
Description | Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities. |
In vitro | METHODS: Human colorectal cancer cells SW620 were treated with Urolithin A (0-30 µM) for 24 h. Cell viability was measured by MTT assay. RESULTS: A dose-dependent decrease in proliferation was observed in Urolithin A-treated cells. [1] METHODS: Human colorectal cancer cells HT29, SW480 and SW620 were treated with Urolithin A (20-100 µM) for 48 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: Treatment of CRC cells with different concentrations of Urolithin A resulted in a significant increase in Cyclin B1 and CDK6, suggesting a strong cell cycle accumulation in G2/M phase. [2] |
In vivo | METHODS: To investigate the effects on Alzheimer's disease (AD), Urolithin A (300 mg/kg, 0.5% carboxymethylcellulose) was administered orally once daily for 14 days to APP/PS1 mouse models. RESULTS: Urolithin A ameliorated cognitive deficits, prevented neuronal apoptosis, and enhanced neurogenesis in APP/PS1 mice.Urolithin A attenuated Aβ deposition and periplaque microglia and astrocyte hyperplasia in the cortex and hippocampus. Urolithin A affects key cell signaling pathways, particularly by enhancing brain AMPK activation, decreasing activation of P65NF-κB and P38MAPK, and inhibiting degradation of Bace1 and APP. [3] |
Molecular Weight | 228.2 |
Formula | C13H8O4 |
Cas No. | 1143-70-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (219.11 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.