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Urolithin A

Urolithin A
Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.
Catalog No. T7174Cas No. 1143-70-0
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Purity:99.66%
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Urolithin A

Purity: 99.66%
Catalog No. T7174Cas No. 1143-70-0

Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$42In Stock
10 mg$66In Stock
25 mg$132In Stock
50 mg$197In Stock
100 mg$337In Stock
200 mg$497In Stock
500 mg$793In Stock
1 mL x 10 mM (in DMSO)$46In Stock
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Product Introduction

Bioactivity
Description
Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.
In vitro
METHODS: Human colorectal cancer cells SW620 were treated with Urolithin A (0-30 µM) for 24 h. Cell viability was measured by MTT assay.
RESULTS: A dose-dependent decrease in proliferation was observed in Urolithin A-treated cells. [1]
METHODS: Human colorectal cancer cells HT29, SW480 and SW620 were treated with Urolithin A (20-100 µM) for 48 h, and the expression levels of target proteins were detected by Western Blot.
RESULTS: Treatment of CRC cells with different concentrations of Urolithin A resulted in a significant increase in Cyclin B1 and CDK6, suggesting a strong cell cycle accumulation in G2/M phase. [2]
In vivo
METHODS: To investigate the effects on Alzheimer's disease (AD), Urolithin A (300 mg/kg, 0.5% carboxymethylcellulose) was administered orally once daily for 14 days to APP/PS1 mouse models.
RESULTS: Urolithin A ameliorated cognitive deficits, prevented neuronal apoptosis, and enhanced neurogenesis in APP/PS1 mice.Urolithin A attenuated Aβ deposition and periplaque microglia and astrocyte hyperplasia in the cortex and hippocampus. Urolithin A affects key cell signaling pathways, particularly by enhancing brain AMPK activation, decreasing activation of P65NF-κB and P38MAPK, and inhibiting degradation of Bace1 and APP. [3]
Chemical Properties
Molecular Weight228.2
FormulaC13H8O4
Cas No.1143-70-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (219.11 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.3821 mL21.9106 mL43.8212 mL219.1060 mL
5 mM0.8764 mL4.3821 mL8.7642 mL43.8212 mL
10 mM0.4382 mL2.1911 mL4.3821 mL21.9106 mL
20 mM0.2191 mL1.0955 mL2.1911 mL10.9553 mL
50 mM0.0876 mL0.4382 mL0.8764 mL4.3821 mL
100 mM0.0438 mL0.2191 mL0.4382 mL2.1911 mL

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