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Urolithin A

Catalog No. T7174Cas No. 1143-70-0

Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.

Urolithin A

Urolithin A

Purity: 99.66%
Catalog No. T7174Cas No. 1143-70-0
Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.
Pack SizePriceAvailabilityQuantity
5 mg$42In Stock
10 mg$66In Stock
25 mg$132In Stock
50 mg$197In Stock
100 mg$337In Stock
200 mg$497In Stock
500 mg$793In Stock
1 mL x 10 mM (in DMSO)$46In Stock
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Purity:99.66%
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Product Introduction

Bioactivity
Description
Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.
In vitro
METHODS: Human colorectal cancer cells SW620 were treated with Urolithin A (0-30 µM) for 24 h. Cell viability was measured by MTT assay.
RESULTS: A dose-dependent decrease in proliferation was observed in Urolithin A-treated cells. [1]
METHODS: Human colorectal cancer cells HT29, SW480 and SW620 were treated with Urolithin A (20-100 µM) for 48 h, and the expression levels of target proteins were detected by Western Blot.
RESULTS: Treatment of CRC cells with different concentrations of Urolithin A resulted in a significant increase in Cyclin B1 and CDK6, suggesting a strong cell cycle accumulation in G2/M phase. [2]
In vivo
METHODS: To investigate the effects on Alzheimer's disease (AD), Urolithin A (300 mg/kg, 0.5% carboxymethylcellulose) was administered orally once daily for 14 days to APP/PS1 mouse models.
RESULTS: Urolithin A ameliorated cognitive deficits, prevented neuronal apoptosis, and enhanced neurogenesis in APP/PS1 mice.Urolithin A attenuated Aβ deposition and periplaque microglia and astrocyte hyperplasia in the cortex and hippocampus. Urolithin A affects key cell signaling pathways, particularly by enhancing brain AMPK activation, decreasing activation of P65NF-κB and P38MAPK, and inhibiting degradation of Bace1 and APP. [3]
Chemical Properties
Molecular Weight228.2
FormulaC13H8O4
Cas No.1143-70-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (219.11 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.3821 mL21.9106 mL43.8212 mL219.1060 mL
5 mM0.8764 mL4.3821 mL8.7642 mL43.8212 mL
10 mM0.4382 mL2.1911 mL4.3821 mL21.9106 mL
20 mM0.2191 mL1.0955 mL2.1911 mL10.9553 mL
50 mM0.0876 mL0.4382 mL0.8764 mL4.3821 mL
100 mM0.0438 mL0.2191 mL0.4382 mL2.1911 mL

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