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Urolithin C

Catalog No. TN7108   CAS 165393-06-6
Synonyms: insulin, Ca channels, Apoptosis, Polyphenols, ROS, mitochondria, anti-diabetic, gut-microbial, Reactive Oxygen Species, Inhibitor, Endogenous Metabolite, glucose-dependent, metabolite, Calcium Channel, β-cells, Urolithin C, ERK1/2, Ca2+ channels, inhibit

Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.

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Urolithin C, CAS 165393-06-6
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
In vitro Urolithin C is a glucose-dependent activator of insulin secretion acting by facilitating L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.Urolithin C enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation as shown by higher phosphorylation levels in INS-1 β-cells[2]. Urolithin C stimulates reactive oxygen species (ROS) formation[2].
In vivo In male Wistar rat, the half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) is 0.831 L/kg and the steady-state volume of distribution (Vss/F) is 55.6 L/kg after the intraperitoneal administration of Urolithin C (10 mg/kg)[3].
Synonyms insulin, Ca channels, Apoptosis, Polyphenols, ROS, mitochondria, anti-diabetic, gut-microbial, Reactive Oxygen Species, Inhibitor, Endogenous Metabolite, glucose-dependent, metabolite, Calcium Channel, β-cells, Urolithin C, ERK1/2, Ca2+ channels, inhibit
Molecular Weight 244.202
Formula C13H8O5
CAS No. 165393-06-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Peipei Yin, et al. Urolithin C, a gut metabolite of ellagic acid, induces apoptosis in PC12 cells through a mitochondria-mediated pathway. RSC Advances. Issue 28, 2017. 2. Morgane Bayle, et al. Development and Validation of a Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Method for the Determination of Urolithin C in Rat Plasma and Its Application to a Pharmacokinetic Study. J Pharm Biomed Anal. 2016 Nov 30;131:33-39. 3. Slimane Toubal, et al. Urolithin C Increases Glucose-Induced ERK Activation Which Contributes to Insulin Secretion. Fundam Clin Pharmacol. 2020 Feb 21.

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