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Valinomycin

Catalog No. TP1072 CAS 2001-95-8

Synonyms: 缬氨霉素, NSC 122023

Valinomycin is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.

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Valinomycin, CAS 2001-95-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Valinomycin is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.

In vivo

Valinomycin is irritating in contact with eyes and skin. Inhalation of Valinomycin can cause respiratory disturbances and even loss of consciousness. The median lethal dose (LD50) of Valinomycin in mice and rabbits was 2.5 mg/kg and 5 mg/kg, respectively. Valinomycin also has various chronic effects, including central and peripheral nervous system damage, eye damage, lens damage, and corneal damage [3].

Synonyms	缬氨霉素, NSC 122023
Molecular Weight	1111.32
Formula	C54H90N6O18
CAS No.	2001-95-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 40 mg/mL (36 mM), Need ultrasonic

DMSO: 20 mg/mL (18 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080. 2. Abdalah R1, Wei L, Francis K, Yu SP. Valinomycin-induced apoptosis in Chinese hamster ovary cells. Neurosci Lett. 2006 Sep 11;405(1-2):68-73. Epub 2006 Jul 20. 3. Kroteń MA, Bartoszewicz M, Swiecicka I. Cereulide and valinomycin, two important natural dodecadepsipeptides with ionophoretic activities. Pol J Microbiol. 2010;59(1):3-10.

Citations

1. Chen X C, Tang G X, Luo W H, et al. Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis. Journal of the American Chemical Society. 2021

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Valinomycin 2001-95-8 PI3K/Akt/mTOR信号通路凋亡微生物学自噬 Antibacterial Antibiotic Apoptosis Autophagy PTEN NSC-122023 Bacterial Inhibitor inhibit NSC 122023 NSC122023 inhibitor

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