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Valinomycin

Valinomycin
Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.
Catalog No. TP1072Cas No. 2001-95-8
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Purity:100%
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Valinomycin

Purity: 100%
Catalog No. TP1072Alias NSC 122023Cas No. 2001-95-8

Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.
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Pack SizePriceAvailabilityQuantity
2 mg$29In Stock
10 mgInquiryIn Stock
25 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$185In Stock
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Product Introduction

Bioactivity
Description
Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.
In vivo
Valinomycin is irritating in contact with eyes and skin. Inhalation of Valinomycin can cause respiratory disturbances and even loss of consciousness. The median lethal dose (LD50) of Valinomycin in mice and rabbits was 2.5 mg/kg and 5 mg/kg, respectively. Valinomycin also has various chronic effects, including central and peripheral nervous system damage, eye damage, lens damage, and corneal damage [3].
AliasNSC 122023
Chemical Properties
Molecular Weight1111.32
FormulaC54H90N6O18
Cas No.2001-95-8
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 40 mg/mL (36 mM), Sonication is recommended.
DMSO: 20 mg/mL (18 mM), Sonication is recommended.
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM0.8998 mL4.4992 mL8.9983 mL44.9915 mL
5 mM0.1800 mL0.8998 mL1.7997 mL8.9983 mL
10 mM0.0900 mL0.4499 mL0.8998 mL4.4992 mL
Ethanol
1mg5mg10mg50mg
20 mM0.0450 mL0.2250 mL0.4499 mL2.2496 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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