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XRP44X
XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
Catalog No. T20759Cas No. 729605-21-4
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Purity:97.51%
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XRP44X
Catalog No. T20759Alias XRP-44-X, XRP 44X, XRP-44X, XRP 44 XCas No. 729605-21-4
XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $50 | In Stock | |
| 25 mg | $73 | In Stock | |
| 50 mg | $113 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $51 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway. |
| Targets&IC50 | Ras:10 nM |
| In vitro | XRP44X is an indirect inhibitor of Net phosphorylation, acting upstream of Erk-1/2 activation. XRP44X inhibits luciferase activity with an IC50 of approximately 10 nM[1]. At 10 nM, XRP44X inhibits the growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells[1]. At 100 nM, it inhibits phosphorylation of Mek-1/2 and Raf-1[1]. |
| In vivo | XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, demonstrates therapeutic potential for refractory asthma[1] by reducing tumor growth and metastasis in nude mice[2]. |
| Alias | XRP-44-X, XRP 44X, XRP-44X, XRP 44 X |
| Molecular Weight | 380.87 |
| Formula | C21H21ClN4O |
| Cas No. | 729605-21-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 36.67 mg/ml (96.27 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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