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XRP44X

Catalog No. T20759   CAS 729605-21-4
Synonyms: XRP-44-X, XRP 44X, XRP-44X, XRP 44 X

XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.

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XRP44X Chemical Structure
XRP44X, CAS 729605-21-4
Pack Size Availability Price/USD Quantity
10 mg In stock $ 50.00
25 mg In stock $ 73.00
50 mg In stock $ 113.00
1 mL * 10 mM (in DMSO) In stock $ 51.00
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Purity: 97.51%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
Targets&IC50 Ras:10 nM
In vitro XRP44X is an indirect inhibitor of Net phosphorylation that acts upstream from Erk-1/2 activation. XRP44X inhibits luciferase activity with the IC50 of~10 nM[1].
XRP44X (10 nM) inhibits cell growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells[1].
XRP44X (100 nM) inhibits phosphorylation of Mek-1/2 and Raf-1[1].
In vivo XRP44X may have therapeutic potential for refractory asthma[1].
XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, inhibits tumor growth and metastasis in mice. XRP44X inhibits tumor growth and metastasis in nude mice. XRP44X decreases the growth of tumours and the formation of metastases in nude mice[2].
Synonyms XRP-44-X, XRP 44X, XRP-44X, XRP 44 X
Molecular Weight 380.87
Formula C21H21ClN4O
CAS No. 729605-21-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 36.67 mg/ml (96.27 mM)

TargetMolReferences and Literature

1. Li TZ, Kim SM, Hur W, Choi JE, Kim JH, Hong SW, Lee EB, Lee JH, Yoon SK. Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition. Gut Liver. 2017 Jan 15;11(1):102-111. doi: 10.5009/gnl15566. PubMed PMID: 27538444; PubMed Central PMCID: PMC5221867. 2. Semenchenko K, Wasylyk C, Cheung H, Tourrette Y, Maas P, Schalken JA, van der Pluijm G, Wasylyk B. XRP44X, an Inhibitor of Ras/Erk Activation of the Transcription Factor Elk3, Inhibits Tumour Growth and Metastasis in Mice. PLoS One. 2016 Jul 18;11(7):e0159531. doi: 10.1371/journal.pone.0159531. eCollection 2016. PubMed PMID: 27427904; PubMed Central PMCID: PMC4948895. 3. Chen J, Sun WL, Wasylyk B, Wang YP, Zheng H. c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells. Anticancer Drugs. 2012 Jan;23(1):98-107. doi: 10.1097/CAD.0b013e32834bc978. PubMed PMID: 21968419. 4. Wasylyk C, Zheng H, Castell C, Debussche L, Multon MC, Wasylyk B. Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Res. 2008 Mar 1;68(5):1275-83. doi: 10.1158/0008-5472.CAN-07-2674. PubMed PMID: 18316589.

Related compound libraries

This product is contained In the following compound libraries:
Microtubule-Targeted Compound Library GPCR Compound Library Bioactive Compounds Library Max Kinase Inhibitor Library Anti-Cancer Metabolism Compound Library Anti-Liver Cancer Compound Library Inhibitor Library Anti-Ovarian Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Obesity Compound Library

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Keywords

XRP44X 729605-21-4 GPCR/G Protein MAPK Ras XRP-44-X Ras/Erk activation inhibit XRP 44X Ras-induced transcription refractory asthma XRP-44X microtubules XRP 44 X Inhibitor inhibitor

 

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