Powder: -20°C for 3 years | In solvent: -80°C for 1 year
XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 50.00 | |
25 mg | In stock | $ 73.00 | |
50 mg | In stock | $ 113.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 51.00 |
Description | XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway. |
Targets&IC50 | Ras:10 nM |
In vitro |
XRP44X is an indirect inhibitor of Net phosphorylation that acts upstream from Erk-1/2 activation. XRP44X inhibits luciferase activity with the IC50 of~10 nM[1]. XRP44X (10 nM) inhibits cell growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells[1]. XRP44X (100 nM) inhibits phosphorylation of Mek-1/2 and Raf-1[1]. |
In vivo |
XRP44X may have therapeutic potential for refractory asthma[1]. XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, inhibits tumor growth and metastasis in mice. XRP44X inhibits tumor growth and metastasis in nude mice. XRP44X decreases the growth of tumours and the formation of metastases in nude mice[2]. |
Synonyms | XRP-44-X, XRP 44X, XRP-44X, XRP 44 X |
Molecular Weight | 380.87 |
Formula | C21H21ClN4O |
CAS No. | 729605-21-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 36.67 mg/ml (96.27 mM)
You can also refer to dose conversion for different animals. More
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XRP44X 729605-21-4 GPCR/G Protein MAPK Ras XRP-44-X Ras/Erk activation inhibit XRP 44X Ras-induced transcription refractory asthma XRP-44X microtubules XRP 44 X Inhibitor inhibitor