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Y15

Catalog No. T7119 CAS 4506-66-5

Synonyms: 1,2,4,5-Benzenetetramine tetrahydrochlor, FAK Inhibitor 14

Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Y15, CAS 4506-66-5

Pack Size	Availability	Price/USD
10 mg	In stock	$ 43.00
25 mg	In stock	$ 63.00
50 mg	In stock	$ 75.00
100 mg	In stock	$ 139.00
200 mg	In stock	$ 198.00
500 mg	In stock	$ 349.00
1 mL * 10 mM (in DMSO)	In stock	$ 40.00

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Purity: 98%

Biological Description

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Description	Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.
In vitro	Y15 inhibited viability in ?thyroid cancer cell lines in a dose-dependent manner[1].
Cell Research	Apoptosis assay was done with PE Annexin V Apoptosis Detection Kit (BD) to identify apoptotic nuclei.?One hundred millimeter plates were seeded with TPC1, K1, BCPAP and TT cells at a concentration of 1 × 10^6 cells in normal growth media.?After overnight incubation, plates were treated with one of several doses of Y15 or left untreated.?After another 24 h of incubation, cells were collected with trypsin, and following centrifugation, were washed with 1× PBS.?Again, cells were centrifuged, PBS was removed and cells were resuspended in binding buffer and filtered through BD mesh tubes.?Annexin V and 7-AAD were added to the solution, vortexed and incubated for 15 minutes in the dark.?Binding buffer was added and the cells were analyzed by flow cytometry within 1 hour.

Synonyms	1,2,4,5-Benzenetetramine tetrahydrochlor, FAK Inhibitor 14
Molecular Weight	284.01
Formula	C6H14Cl4N4
CAS No.	4506-66-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 59 mg/mL (207.74 mM), Sonification and heating are recommended.

References and Literature

1. O'Brien S, Golubovskaya VM, Conroy J,et al.FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics[J].Oncotarget. 2014 Sep 15;5(17):7945-59. 2. Zheng D , Golubovskaya V , Kurenova E , et al. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts[J]. Molecular Carcinogenesis, 2010, 49(2):0-0. 3. Hochwald S N , Nyberg C , Zheng M , et al. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer[J]. Cell Cycle, 2009, 8(15):2435-2443.

Citations

1. Sun Y, Qian Y, Chen C, et al. Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway. Journal of Experimental & Clinical Cancer Research. 2022, 41(1): 1-22 2. Hu S, Wang Z, Jin C, et al. Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair. Journal of Tissue Engineering. 2022, 13: 20417314221122123

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Kinase Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Angiogenesis related Compound Library Bioactive Compound Library Anti-Cancer Compound Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Y15 4506-66-5 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors FAK PTK2 protein tyrosine kinase 2 FAK Inhibitor-14 FAK Inhibitor14 Y-15 PTK2 Focal adhesion kinase 1,2,4,5-Benzenetetramine tetrahydrochlor Y 15 Inhibitor FAK Inhibitor 14 inhibit FAK inhibitor Y15 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.