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Zonisamide

Catalog No. T0267 CAS 68291-97-4

Synonyms: AD 810, CI 912

Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels results in a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may lower the uptake of the inhibitory neurotransmitter GABA while increasing the uptake of the excitatory neurotransmitter glutamate.

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Zonisamide, CAS 68291-97-4

Pack Size	Availability	Price/USD
50 mg	In stock	$ 40.00
100 mg	In stock	$ 59.00
200 mg	In stock	$ 79.00
500 mg	In stock	$ 134.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.94%

Purity: 99.9%

Purity: 99.76%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

CA II (human):35.2 nM (Ki), CA V (human):20.6 nM (Ki)

Synonyms	AD 810, CI 912
Molecular Weight	212.23
Formula	C8H8N2O3S
CAS No.	68291-97-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 21.2 mg/mL (100 mM)

References and Literature

1. Sonsalla PK, et al. Exp Neurol, 2010, 221(2), 329-334. 2. Tanabe M, et al. Naunyn Schmiedebergs Arch Pharmacol, 2005, 372(2), 107-114. 3. Hayakawa T, et al. Eur J Pharmacol, 1994, 257(1-2), 131-136. 4. Ueda Y, et al. Brain Res Mol Brain Res, 2003, 116(1-2), 1-6. 5. Okada M, et al. Br J Pharmacol, 1998, 124(6), 1277-1285. 6. Tian J, Wu Q, He Y, et al. Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress[J]. Acta Pharmacologica Sinica. 2020: 1-11.

Citations

1. Tian J, Wu Q, He Y, et al. Zonisamide, an antiepileptic drug, alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress. Acta Pharmacologica Sinica. 2021, 42(3): 393-403.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library Calcium Channel Compound Library Anti-Cancer Metabolism Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zonisamide 68291-97-4 Membrane transporter/Ion channel Metabolism Calcium Channel Carbonic Anhydrase Sodium Channel parkinson’s disease seizure epilepsy Carbonate dehydratase AD-810 Apoptosis Inhibitor cardiac hypertrophy AD 810 cardiac fibroblasts inhibit AD810 CI-912 CI912 NRCMs CI 912 SH-SY5Y inhibitor

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