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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $36 | In Stock | |
2 mg | $51 | In Stock | |
5 mg | $80 | In Stock | |
10 mg | $147 | In Stock | |
25 mg | $322 | In Stock | |
50 mg | $572 | In Stock | |
100 mg | $815 | In Stock | |
1 mL x 10 mM (in DMSO) | $105 | In Stock |
Description | A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor. |
Targets&IC50 | eEF2:280 nM |
In vitro | A-484954 is a selective eEF2K inhibitor and little activity against a wide panel of serine/threonine and tyrosine kinases. In the enzymatic assay, the IC50 value of A-484954 is increased as the concentration of ATP increased but unaffected by increasing concentrations of calmodulin [1]. |
In vivo | Long-term A-484954 treatment inhibits MCT-induced increases PA pressure. Furthermore, A-484954 inhibits MCT-induced NADPH oxidase-1 expression and ROS generation as well as matrix metalloproteinase-2 activation [2]. A484954 causes relaxation in E (+) and E (-) aorta or mesenteric artery precontracted with NA. Pretreatment with L-NAME but not indomethacin or cimetidine partially inhibits the A484954-induced relaxation in mesenteric artery [3]. |
Alias | A 484954 |
Molecular Weight | 289.29 |
Formula | C13H15N5O3 |
Cas No. | 142557-61-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | H2O: Insoluble DMSO: 20 mg/mL (69.13 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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