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A-484954

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Purity:97.47%

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COA HPLC HNMR

A-484954

Catalog No. TQ0137Cas No. 142557-61-7

A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.

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Pack Size	Price	Availability
1 mg	$36	In Stock
2 mg	$51	In Stock
5 mg	$80	In Stock
10 mg	$147	In Stock
25 mg	$322	In Stock
50 mg	$572	In Stock
100 mg	$815	In Stock
1 mL x 10 mM (in DMSO)	$105	In Stock

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Product Introduction

Bioactivity

Description	A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.
Targets&IC50	eEF2:280 nM
In vitro	A-484954 is a selective eEF2K inhibitor and little activity against a wide panel of serine/threonine and tyrosine kinases. In the enzymatic assay, the IC50 value of A-484954 is increased as the concentration of ATP increased but unaffected by increasing concentrations of calmodulin [1].
In vivo	Long-term A-484954 treatment inhibits MCT-induced increases PA pressure. Furthermore, A-484954 inhibits MCT-induced NADPH oxidase-1 expression and ROS generation as well as matrix metalloproteinase-2 activation [2]. A484954 causes relaxation in E (+) and E (-) aorta or mesenteric artery precontracted with NA. Pretreatment with L-NAME but not indomethacin or cimetidine partially inhibits the A484954-induced relaxation in mesenteric artery [3].
Alias	A 484954

Chemical Properties

Molecular Weight	289.29
Formula	C13H15N5O3
Cas No.	142557-61-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: Insoluble

DMSO: 20 mg/mL (69.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4567 mL	17.2837 mL	34.5674 mL	172.8369 mL
5 mM	0.6913 mL	3.4567 mL	6.9135 mL	34.5674 mL
10 mM	0.3457 mL	1.7284 mL	3.4567 mL	17.2837 mL
20 mM	0.1728 mL	0.8642 mL	1.7284 mL	8.6418 mL
50 mM	0.0691 mL	0.3457 mL	0.6913 mL	3.4567 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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