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AGK2

AGK2
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Purity:99.17%
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AGK2

Catalog No. T6371Cas No. 304896-28-4
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
2 mg$41In Stock
5 mg$67In Stock
10 mg$97In Stock
25 mg$197In Stock
50 mg$313In Stock
100 mg$493In Stock
500 mg$1,090In Stock
1 mL x 10 mM (in DMSO)$74In Stock
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Product Introduction

Bioactivity
Description
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
Targets&IC50
SIRT2:3.5 μM
In vitro
In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3]
In vivo
In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1]
Chemical Properties
Molecular Weight434.27
FormulaC23H13Cl2N3O2
Cas No.304896-28-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 4.3 mg/mL (10 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3027 mL11.5136 mL23.0271 mL115.1357 mL
5 mM0.4605 mL2.3027 mL4.6054 mL23.0271 mL
10 mM0.2303 mL1.1514 mL2.3027 mL11.5136 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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