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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
2 mg | $41 | In Stock | |
5 mg | $67 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $197 | In Stock | |
50 mg | $313 | In Stock | |
100 mg | $493 | In Stock | |
500 mg | $1,090 | In Stock | |
1 mL x 10 mM (in DMSO) | $74 | In Stock |
Description | AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor. |
Targets&IC50 | SIRT2:3.5 μM |
In vitro | In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. [1] AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. [2] SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability. [3] |
In vivo | In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation. [1] |
Molecular Weight | 434.27 |
Formula | C23H13Cl2N3O2 |
Cas No. | 304896-28-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4.3 mg/mL (10 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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