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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $79 | In Stock | |
5 mg | $193 | In Stock | |
10 mg | $288 | In Stock | |
25 mg | $487 | In Stock | |
50 mg | $693 | In Stock | |
100 mg | $963 | In Stock | |
500 mg | $1,930 | In Stock | |
1 mL x 10 mM (in DMSO) | $219 | In Stock |
Description | Allitinib (AST-1306) (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1] |
Targets&IC50 | ErbB2:3 nM, ERB4:0.8 nM, EGFR (L858R/T790M):12 nM, EGFR:0.5 nM |
In vitro | AST1306 (AST-1306; 0.19-6.25 μM; 72 hours) inhibits the growth of HIH3T3-EGFR T790M/L858R cells[1]. AST1306 (0.001-1.0 μM; 4 hours) is more than 3000-fold selective for ErbB family kinases over other kinase families[1]. In A549, Calu-3, and SK-OV-3 cells, AST1306 inhibits tyrosine kinase activation and downstream signaling pathways, and dose-dependently and markedly inhibits EGF-induced EGFR phosphorylation in A549 cells[1]. |
In vivo | AST1306 (AST-1306; oral; 25-100 mg/kg) significantly inhibited tumor growth in SK-OV-3 and Calu-3 xenograft models[1]. |
Alias | AST-1306, ALS 1306 |
Molecular Weight | 448.88 |
Formula | C24H18ClFN4O2 |
Cas No. | 897383-62-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (122.53 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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