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Allitinib

Allitinib
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Purity:99.28%
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Allitinib

Catalog No. T14336Cas No. 897383-62-9
Allitinib (AST-1306) (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]
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Pack SizePriceAvailabilityQuantity
1 mg$79In Stock
5 mg$193In Stock
10 mg$288In Stock
25 mg$487In Stock
50 mg$693In Stock
100 mg$963In Stock
500 mg$1,930In Stock
1 mL x 10 mM (in DMSO)$219In Stock
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Product Introduction

Bioactivity
Description
Allitinib (AST-1306) (AST-1306) has anti-cancer activity,and it is an irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. [1]
Targets&IC50
ErbB2:3 nM, ERB4:0.8 nM, EGFR (L858R/T790M):12 nM, EGFR:0.5 nM
In vitro
AST1306 (AST-1306; 0.19-6.25 μM; 72 hours) inhibits the growth of HIH3T3-EGFR T790M/L858R cells[1]. AST1306 (0.001-1.0 μM; 4 hours) is more than 3000-fold selective for ErbB family kinases over other kinase families[1]. In A549, Calu-3, and SK-OV-3 cells, AST1306 inhibits tyrosine kinase activation and downstream signaling pathways, and dose-dependently and markedly inhibits EGF-induced EGFR phosphorylation in A549 cells[1].
In vivo
AST1306 (AST-1306; oral; 25-100 mg/kg) significantly inhibited tumor growth in SK-OV-3 and Calu-3 xenograft models[1].
AliasAST-1306, ALS 1306
Chemical Properties
Molecular Weight448.88
FormulaC24H18ClFN4O2
Cas No.897383-62-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (122.53 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2278 mL11.1388 mL22.2777 mL111.3883 mL
5 mM0.4456 mL2.2278 mL4.4555 mL22.2777 mL
10 mM0.2228 mL1.1139 mL2.2278 mL11.1388 mL
20 mM0.1114 mL0.5569 mL1.1139 mL5.5694 mL
50 mM0.0446 mL0.2228 mL0.4456 mL2.2278 mL
100 mM0.0223 mL0.1114 mL0.2228 mL1.1139 mL

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