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Artemisone

Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.

Catalog No. T14324Cas No. 255730-18-8

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Purity:99.90%

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Artemisone

Catalog No. T14324Cas No. 255730-18-8

Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$79	In Stock
5 mg	$173	In Stock
10 mg	$273	In Stock
25 mg	$451	In Stock
50 mg	$636	In Stock
100 mg	$858	In Stock
1 mL x 10 mM (in DMSO)	$190	In Stock

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Product Introduction

Bioactivity

Description	Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.
Targets&IC50	P. falciparum:0.83 nM
In vitro	Artemisone inhibits 3D7 and K1 P. falciparum with IC50 values of 0.88±0.59 nM and 1.23±0.64 nM, respectively.
In vivo	Artemisone, when administered subcutaneously at doses of 3, 1, 0.3, and 0.1 mg/kg in conjunction with other antimalarials, demonstrates an enhanced effectiveness against the chloroquine-resistant P. yoelii NS strain[1]. Moreover, it is effective at inhibiting parasitemia in the P. berghei NY susceptible strain, achieving an ED50 of 9.62 mg/kg through the subcutaneous route and 11.67 mg/kg when given orally[1].
Alias	BAY 44-9585, Artemifone

Chemical Properties

Molecular Weight	401.52
Formula	C₁₉H₃₁NO₆S
Cas No.	255730-18-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 130 mg/mL (323.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4905 mL	12.4527 mL	24.9054 mL	124.5268 mL
5 mM	0.4981 mL	2.4905 mL	4.9811 mL	24.9054 mL
10 mM	0.2491 mL	1.2453 mL	2.4905 mL	12.4527 mL
20 mM	0.1245 mL	0.6226 mL	1.2453 mL	6.2263 mL
50 mM	0.0498 mL	0.2491 mL	0.4981 mL	2.4905 mL
100 mM	0.0249 mL	0.1245 mL	0.2491 mL	1.2453 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc