Azumolene (EU4093 free base)

Azumolene is a direct acting, skeletal muscle relaxant with structural similarities to dantrolene sodium in that the para-nitro phenyl group of dantrolene sodium is replaced by a para-bromo phenyl group.2.The effect of Azumolene on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg kg-1.This dose of Azumolene reduces the amplitude of the twitch to 31.9% of the control value.By comparison, dantrolene sodium reduced the twitch amplitude to 31.3% of the control value at a dose of 5 mg kg-1.3.The contraction of intrafusal muscle as measured by the response of spindle afferent discharge was also reduced by Azumolene.4.The most significant difference between the effect of Azumolene and dantrolene sodium on the contraction of intrafusal muscle was that Azumolene had an appreciable depressant action at high stimulation frequencies at which dantrolene sodium had only a minimal relaxant effect on the intrafusal muscle contraction.