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Batimastat

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Purity:99.5%

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COA LCMS HNMR

Batimastat

Catalog No. T6011Cas No. 130370-60-4

Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angiogenesis, tumor growth and invasion, and metastasis.

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Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$113	In Stock
10 mg	$178	In Stock
25 mg	$361	In Stock
50 mg	$575	In Stock
100 mg	$823	In Stock
1 mL x 10 mM (in DMSO)	$119	In Stock

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Product Introduction

Bioactivity

Description	Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angiogenesis, tumor growth and invasion, and metastasis.
Targets&IC50	MMP1:3 nM, MMP7:6 nM, MMP9:4 nM, MMP2:4 nM, MMP3:20 nM
In vitro	Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. [1]Batimastat exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site. [2]
In vivo	Batimastat can inhibit metastatic spread and growth of B16-BL6 murine melanoma. [1] In an orthotopic colon tumor model in mice, timastat treatment results in inhibition of primary tumor growth (by 50%), local/regional spread(from 67% to 35%), and distant metastasis(from 30% to 10%).[3]Batimastat reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organization in vascular structures. [4]
Kinase Assay	For luciferase assay, FG-9307 cells are transfected with the firefly NF-κB-specific luciferase reporter vector pNFκB-Met-Luc2. Transfection efficiency is monitored by co-transfection with the pSEAP2 control vector, which constitutively expresses the human secreted enhanced alkaline phosphatase (SEAP). Then the cells are treated with Resiquimod (R848, 1?μg/mL), CQ (10?μM), CQ plus R848 or PBS and incubated at 22°C for 24?h. The culture medium of the transfectants is then analyzed for luciferase activity and SEAP activity using Luciferase Assay Kit and the Great EscAPe? SEAP Chemiluminescence Detection Kit, respectively. The assay is performed three times.
Alias	BB94

Chemical Properties

Molecular Weight	477.64
Formula	C23H31N3O4S2
Cas No.	130370-60-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 47.8 mg/mL (100 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0936 mL	10.4681 mL	20.9363 mL	104.6813 mL
5 mM	0.4187 mL	2.0936 mL	4.1873 mL	20.9363 mL
10 mM	0.2094 mL	1.0468 mL	2.0936 mL	10.4681 mL
20 mM	0.1047 mL	0.5234 mL	1.0468 mL	5.2341 mL
50 mM	0.0419 mL	0.2094 mL	0.4187 mL	2.0936 mL
100 mM	0.0209 mL	0.1047 mL	0.2094 mL	1.0468 mL

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