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Bepridil hydrochloride

Bepridil hydrochloride
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Purity:99.71%
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Bepridil hydrochloride

Catalog No. T5391Cas No. 68099-86-5
Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.
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Pack SizePriceAvailabilityQuantity
5 mg$41In Stock
10 mg$54In Stock
25 mg$98In Stock
50 mg$135In Stock
100 mg$189In Stock
1 mL x 10 mM (in DMSO)$45In Stock
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Product Introduction

Bioactivity
Description
Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.
In vitro
Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2].
In vivo
The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1].
AliasCERM 1978
Chemical Properties
Molecular Weight403
FormulaC24H35ClN2O
Cas No.68099-86-5
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 130 mg/mL (322.58 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4814 mL12.4069 mL24.8139 mL124.0695 mL
5 mM0.4963 mL2.4814 mL4.9628 mL24.8139 mL
10 mM0.2481 mL1.2407 mL2.4814 mL12.4069 mL
20 mM0.1241 mL0.6203 mL1.2407 mL6.2035 mL
50 mM0.0496 mL0.2481 mL0.4963 mL2.4814 mL
100 mM0.0248 mL0.1241 mL0.2481 mL1.2407 mL

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