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Besifovir

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Purity:98%

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COA HNMR

Besifovir

Catalog No. T5832Cas No. 441785-25-7

Besifovir, a parent drug converted by LB80380, further metabolizes to its active form, LB80317. LB80380 is potent antiviral agent against hepatitis B virus (HBV).

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Pack Size	Price	Availability
1 mg	$57	In Stock
2 mg	$83	In Stock
5 mg	$139	In Stock
10 mg	$217	In Stock
25 mg	$395	In Stock
50 mg	$588	In Stock
100 mg	$838	In Stock
1 mL x 10 mM (in DMSO)	$129	In Stock

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Product Introduction

Bioactivity

Description

Besifovir, a parent drug converted by LB80380, further metabolizes to its active form, LB80317. LB80380 is potent antiviral agent against hepatitis B virus (HBV).

In vivo

Besifovir (LB80380) is a relatively new oral acyclic nucleotide phosphonate. Areas covered: LB80380 is a prodrug of LB80331 and LB80317. It is rapidly absorbed when taken orally. Escalating doses of besifovir produce linear increase of the plasma concentration. Doses above 60mg are effective for inhibiting HBV in human. Using 60mg as an example, the maximal concentration of LB80331 in plasma is 397 ng/mL.

Chemical Properties

Molecular Weight	299.22
Formula	C10H14N5O4P
Cas No.	441785-25-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (835.51 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3420 mL	16.7101 mL	33.4202 mL	167.1011 mL
5 mM	0.6684 mL	3.3420 mL	6.6840 mL	33.4202 mL
10 mM	0.3342 mL	1.6710 mL	3.3420 mL	16.7101 mL
20 mM	0.1671 mL	0.8355 mL	1.6710 mL	8.3551 mL
50 mM	0.0668 mL	0.3342 mL	0.6684 mL	3.3420 mL
100 mM	0.0334 mL	0.1671 mL	0.3342 mL	1.6710 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc