Shopping Cart

Remove All

Your shopping cart is currently empty

BGT226

Select Batch

Purity:99.67%

Resource Download

COA HNMR HPLC LCMS

BGT226

Catalog No. T6072LCas No. 915020-55-2

BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$116	In Stock
10 mg	$197	In Stock
25 mg	$433	In Stock
50 mg	$638	In Stock
100 mg	$892	In Stock
1 mL x 10 mM (in DMSO)	$158	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "BGT226"

Product Introduction

Bioactivity

Description	BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
In vitro	Growth inhibition experiment showed that BGT226 had antitumor activity. BGT226 significantly inhibited cell growth with IC50 < 20 nM. BGT226 also induced cancer cell apoptosis at nanomolar concentration, IC50 ≤ 25 nM[1][2][3].
In vivo	BGT226 significantly delayed tumor growth on the transplanted tumor animal model. This effect was dose-dependent, accompanied by inhibition of p-p70 S6 kinase cytoplasmic expression and autophagy body formation[2].
Alias	BGT226 free base, NVP-BGT226

Chemical Properties

Molecular Weight	534.53
Formula	C28H25F3N6O2
Cas No.	915020-55-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (121.6 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8708 mL	9.3540 mL	18.7080 mL	93.5401 mL
5 mM	0.3742 mL	1.8708 mL	3.7416 mL	18.7080 mL
10 mM	0.1871 mL	0.9354 mL	1.8708 mL	9.3540 mL
20 mM	0.0935 mL	0.4677 mL	0.9354 mL	4.6770 mL
50 mM	0.0374 mL	0.1871 mL	0.3742 mL	1.8708 mL
100 mM	0.0187 mL	0.0935 mL	0.1871 mL	0.9354 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc