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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $92 | In Stock | |
2 mg | $135 | In Stock | |
5 mg | $228 | In Stock | |
10 mg | $397 | In Stock | |
25 mg | $663 | In Stock | |
50 mg | $945 | In Stock | |
100 mg | $1,280 | In Stock | |
500 mg | $2,570 | In Stock | |
1 mL x 10 mM (in DMSO) | $253 | In Stock |
Description | BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2]. |
In vitro | BI-671800 (compound A) exhibits low nM potency as a potent small-molecule antagonist of human or mouse CRTH2 in transfected cells[1]. |
In vivo | BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice[1]. BI-671800 (compound A) also effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals[3]. |
Alias | AP-761, Cmpd A |
Molecular Weight | 501.5 |
Formula | C25H26F3N5O3 |
Cas No. | 1093108-50-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 130 mg/mL (259.22 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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