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BioE-1115

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Catalog No. T10547Cas No. 1268863-35-9

BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).

BioE-1115

BioE-1115

🥰Excellent
Purity: 97.38%
Catalog No. T10547Cas No. 1268863-35-9
BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).
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5 mg28 €In Stock
10 mg37 €In Stock
25 mgInquiryIn Stock
50 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)28 €In Stock
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Purity:97.38%
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Product Introduction

Bioactivity
Description
BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).
Targets&IC50
CK2α:10 μM
In vitro
In HepG2 cells, BioE-1115 (>10μM) treatment shows a significant reduction in SREBP activity, without any observable effects on cell morphology or growth rate. In HEK293 cells, BioE-1115 shows a dose-dependent loss of PASK phosphorylation (IC50 =1μM)[1].
In vivo
In male Sprague-Dawley rats, BioE-1115 (10, 30 and 100 mg/kg) treatment shows a dose-dependent suppression of the expression of Gpat1, Fasn, and all other SREBP-1c target genes analyzed. SREBP-1 maturation in the liver is also suppressed in BioE-1115 treated rats. A calculated measure of insulin resistance, HOMA-IR, is decreased in a dose-dependent manner by BioE-1115 administration. Hepatic and serum TAG are decreased in a dose-dependent manner by BioE-1115 administration. BioE-1115 treatment causes a significant decrease in serum glucose. Both SREBP-1c and SREBP-1a mRNA are modestly decreased at the highest doses. Neither dose of BioE-1115 causes a significant change in either liver weight or body weight[1].
Chemical Properties
Molecular Weight339.36
FormulaC19H18FN3O2
Cas No.1268863-35-9
SmilesCC(C)N(C)c1nc2cc(ccc2nc1-c1ccc(F)cc1)C(O)=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (176.80 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9467 mL14.7336 mL29.4672 mL147.3362 mL
5 mM0.5893 mL2.9467 mL5.8934 mL29.4672 mL
10 mM0.2947 mL1.4734 mL2.9467 mL14.7336 mL
20 mM0.1473 mL0.7367 mL1.4734 mL7.3668 mL
50 mM0.0589 mL0.2947 mL0.5893 mL2.9467 mL
100 mM0.0295 mL0.1473 mL0.2947 mL1.4734 mL

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