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CA-4948
🥰Excellent
Catalog No. T9027Cas No. 1801344-14-8
Alias Emavusertib
CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
CA-4948
🥰Excellent
Purity: 99.62%
Catalog No. T9027Alias EmavusertibCas No. 1801344-14-8
CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 2 mg | $44 | In Stock | |
| 5 mg | $70 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $178 | In Stock | |
| 50 mg | $328 | In Stock | |
| 100 mg | $563 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $76 | In Stock |
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Purity:99.62%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity. |
| In vitro | CA-4948, demonstrated good cellular activity in ABC DLBCL and AML cell lines.?Inhibition of TLR signaling leading to decreased IL-6 levels was also observed in whole blood assays.?CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.?CA-4948 was well tolerated in toxicity studies in both mouse and dog at efficacious exposure.?The overall profile of CA-4948 prompted us to select it as a clinical candidate for evaluation in patients with relapsed or refractory hematologic malignancies including non-Hodgkin lymphoma and acute myeloid leukemia[2]. |
| Alias | Emavusertib |
| Molecular Weight | 491.5 |
| Formula | C24H25N7O5 |
| Cas No. | 1801344-14-8 |
| Smiles | Cc1cc(ccn1)-c1nc(co1)C(=O)Nc1cc2oc(nc2nc1N1CC[C@@H](O)C1)N1CCOCC1 |
| Relative Density. | 1.457 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 0.1 mg/mL (insoluble) DMSO: 27.78 mg/mL (56.52 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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