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CAY10650

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Purity:95.56%

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COA HPLC HNMR

CAY10650

Catalog No. TQ0105Cas No. 1233706-88-1

CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).

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Pack Size	Price	Availability
1 mg	$47	In Stock
5 mg	$167	In Stock
10 mg	$288	In Stock
25 mg	$485	In Stock
50 mg	$693	In Stock
100 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$173	In Stock

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Product Introduction

Bioactivity

Description	CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).
Targets&IC50	CPLA2α:12 nM
In vivo	CAY10650 demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. Chinese hamsters (n = 6/group) were infected with parasite-laden contact lenses and treated with cPLA2α inhibitors (AACOCF3 and CAY10650) 50 μg/5 μl was injected with topical eye-drop under the contact lens of an infected cornea three times a day for 6 days and topically on days 7–14 postinfection. Animals were anesthetized and sacrificed 15 days after the application of cPLA2α inhibitors. Treatment with the AACOCF3 and CAY10650 had a profound effect on the severity and chronicity of keratitis. In addition, hamsters treated with AACOCF3 had significantly less severe keratitis as compared with the CAY10650 group.

Chemical Properties

Molecular Weight	471.5
Formula	C28H25NO6
Cas No.	1233706-88-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 40 mg/mL (84.84 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1209 mL	10.6045 mL	21.2089 mL	106.0445 mL
5 mM	0.4242 mL	2.1209 mL	4.2418 mL	21.2089 mL
10 mM	0.2121 mL	1.0604 mL	2.1209 mL	10.6045 mL
20 mM	0.1060 mL	0.5302 mL	1.0604 mL	5.3022 mL
50 mM	0.0424 mL	0.2121 mL	0.4242 mL	2.1209 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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