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Chimmitecan
🥰Excellent
Catalog No. T60123Cas No. 185425-25-6
Alias (S)-9-Allyl-10-hydroxycamptothecin
Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent topoisomerase I inhibitor with exceptional in vitro and in vivo activity.
Chimmitecan
🥰Excellent
Purity: 98.5%
Catalog No. T60123Alias (S)-9-Allyl-10-hydroxycamptothecinCas No. 185425-25-6
Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent topoisomerase I inhibitor with exceptional in vitro and in vivo activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $95 | In Stock | |
| 5 mg | $218 | In Stock | |
| 10 mg | $308 | In Stock | |
| 25 mg | $476 | In Stock | |
| 50 mg | $678 | In Stock | |
| 100 mg | $936 | In Stock | |
| 200 mg | $1,260 | In Stock |
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Purity:98.5%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent topoisomerase I inhibitor with exceptional in vitro and in vivo activity. |
| In vitro | Chimmitecan was highly cytotoxic (IC50s in the nanomolar range) to a wide variety of tumor cells, including leukemia, lung cancer, gastric cancer, hepatocellular cancer, colon cancer, breast cancer, ovarian cancer, and cervical cancer, and rhabdomyosarcoma cells[1]. |
| In vivo | Chimmitecan (i.v. administration, twice for HCT-116 and thrice for the other tumors per week) caused a dramatic and dose-dependent suppression of tumor growth in all four tumor models. At a dosage of 15 mg/kg, the T/C (%) values were 17.6% (HCT-116), 24.2% (MDA-MB-435), 28.2% (BEL-7402), and 23.0% (A549). when given thrice per week for 2 weeks, chimmitecan (orally administration) inhibited the growth of the A549 xenograft at dosages as low as 4.5 mg/kg, and significant antitumor activity was observed at a dosage of 9 mg/kg[1]. |
| Alias | (S)-9-Allyl-10-hydroxycamptothecin |
| Molecular Weight | 404.42 |
| Formula | C23H20N2O5 |
| Cas No. | 185425-25-6 |
| Smiles | C(C)[C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC=C(O)C5CC=C)COC1=O |
| Relative Density. | 1.49 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.05 mg/mL (10 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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