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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $39 | In Stock | |
10 mg | $55 | In Stock | |
25 mg | $113 | In Stock | |
50 mg | $183 | In Stock | |
100 mg | $289 | In Stock | |
200 mg | $428 | In Stock | |
1 mL x 10 mM (in DMSO) | $40 | In Stock |
Description | Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood. |
Targets&IC50 | HMG-CoA reductase:0.47 mM |
In vitro | In the treatment of arteriosclerosis in rats, Clinofibrate significantly reduces high plasma cholesterol levels. When used in CAPD patients, it effectively decreases very low-density lipoprotein levels. Typically, Clinofibrate (600 mg/daily) reduces serum triglycerides by 36% and very low-density lipoprotein triglycerides by 48%. Additionally, it ameliorates abnormalities in low-density and high-density lipoprotein compositions, markedly increasing the content of high-density lipoprotein cholesterol. |
In vivo | Clinofibrate, with an IC50 of 40 μM, acts on the activity of human liver 3α-hydroxysteroid dehydrogenase. |
Alias | S-8527, Lipoclin |
Molecular Weight | 468.58 |
Formula | C28H36O6 |
Cas No. | 30299-08-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 87 mg/mL (185.7 mM) Ethanol: 87 mg/mL (185.7 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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