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Dacarbazine
🥰Excellent
Catalog No. T1120Cas No. 4342-03-4
Alias Imidazole Carboxamide, DTIC-Dome
Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.
Dacarbazine
🥰Excellent
Purity: 100%
Catalog No. T1120Alias Imidazole Carboxamide, DTIC-DomeCas No. 4342-03-4
Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $32 | In Stock | |
| 100 mg | $50 | In Stock | |
| 200 mg | $58 | In Stock | |
| 1 g | $97 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dacarbazine (DTIC-Dome) is an antineoplastic agent. It has significant activity against melanomas. |
| In vitro | Treatment of Dacarbazine sensitizes melanomas to lysis of peptide-specific CTL and it is is mediated through Fas-independent pathway[2]. |
| In vivo | Treatment of combination of Axitinib and DTIC demonstrates significant antitumor activity against melanoma flank xenografts, reduces tumor cell proliferation and decreases the area of tumor necrosis and increases apoptosis. It also reduces meta-tasis-related factors and prolongs lifespan in mice[3]. |
| Cell Research | Apotosis assay: UACC903 (UACC) cells treated with or without DTIC (20 μM) for 48 h are incubated with agonist anti-Fas Ab, CH-11 (500 ng/ml), for 5 and 16 h, respectively. To distinguish whether death/apoptosis is mediated by FasR, blocking anti-Fas Ab ZB4 (2 mg/ml) is added in the corresponding groups. At the end of incubation, cells are harvested and stained with propidium iodide and FITC-annexin V (BD PharMingen) for detecting apoptosis according to the instruction provided by the company. Ten thousand cells from each group are collected, and dead and apoptotic cells are analyzed without gating using CellQuest software. (Only for Reference) |
| Alias | Imidazole Carboxamide, DTIC-Dome |
| Molecular Weight | 182.18 |
| Formula | C6H10N6O |
| Cas No. | 4342-03-4 |
| Smiles | N(=NN(C)C)C1=C(C(N)=O)N=CN1 |
| Relative Density. | 1.3206 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 3 mg/mL (16.46 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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