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Dihydrorotenone
Catalog No. TN1586Cas No. 6659-45-6
Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
Dihydrorotenone
Catalog No. TN1586Cas No. 6659-45-6
Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $115 | In Stock | |
| 5 mg | $279 | In Stock | |
| 10 mg | $443 | In Stock | |
| 25 mg | $733 | In Stock | |
| 50 mg | $987 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $335 | In Stock |
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Purity:99.58%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome. |
| In vitro | Dihydrorotenone arrested human plasma cancer cells at the G0/G1 phase of the cell cycle. Dihydrorotenone inhibited cyclin D2 transactivation, thus inhibiting its mRNA expression. In addition, Dihydrorotenone upregulated the cell cycle repressors p21 and p53. Dihydrorotenone also increased the phosphorylation level of p53, suggesting the upregulated transactivation function of p53, which was confirmed by the induction of p21, a substrate of activated p53. Moreover, Dihydrorotenone downregulated AKT and ERK phosphorylation, an incentive of cell cycle progression. |
| Molecular Weight | 396.43 |
| Formula | C23H24O6 |
| Cas No. | 6659-45-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 27.5 mg/mL (69.37 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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