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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $34 | In Stock | |
100 mg | $50 | In Stock | |
200 mg | $63 | In Stock | |
1 mL x 10 mM (in DMSO) | $37 | In Stock |
Description | Dithranol (cignoline) is an anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS. |
Kinase Assay | THP-1 and HEK293 cells are transiently transfected using DEAE-dextran and Polyfect reagent, respectively. Plasmids transfected contain genes coding for the NF-κB-dependent pELAM-luc luciferase reporter, TLR2, TLR4, CD14, and MD2. Cells (5×105 THP-1 or 1×105 HEK293) are added to 12-well plates, washed after 18 h, and stimulated for 5 h. Cells are then lysed with reporter lysis buffer as directed, and lysates are analyzed for luminescence using Promega luciferase substrate and a Monolight 3010 luminometer. |
Alias | 1,8,9-trihydroxyanthracene, cignoline, Anthralin |
Molecular Weight | 226.23 |
Formula | C14H10O3 |
Cas No. | 1143-38-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | Chloroform: 41 mg/mL DMSO: 10 mM | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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