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Dp44mT
🥰Excellent
Catalog No. T6821Cas No. 152095-12-0
Dp44mT, a effective iron chelator, has selective antitumor activity.
Dp44mT
🥰Excellent
Purity: 100%
Catalog No. T6821Cas No. 152095-12-0
Dp44mT, a effective iron chelator, has selective antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $39 | In Stock | |
| 25 mg | $64 | In Stock | |
| 50 mg | $113 | In Stock | |
| 100 mg | $197 | In Stock | |
| 200 mg | $258 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $43 | In Stock |
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CitedSelect Batch
Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dp44mT, a effective iron chelator, has selective antitumor activity. |
| In vitro | In MDA-MB-231 cells, Dp44mT selectively targets towards topoisomerase topo2α resulting in DNA damage. Dp44mT inhibits antiproliferative effects significantly with IC50 of 30 nM, 60 nM, and 60 nM for SK-N-MC, SK-Mel-28, and MCF-7 cells, respectively, while showing no effects on normal MRC-5 fibroblasts. In SK-N-MC neuroepithelioma and M109 cells,Dp44mT inhibits cellular Fe uptake from Fe-Tf , and induces cell apoptosis. Dp44mT, as a Pgp substrate, also overcomes multidrug resistance by the hijacking of lysosomal P-glycoprotein (Pgp). |
| In vivo | Dp44mT (0.4 mg/kg, i.v.) inhibits M109 tumor implanted in CD2F1 mice by a dose-dependent manner. |
| Cell Research | SK-N-MC, SK-Mel-28, MCF-7 and MRC-5 cells are incubated in the presence and absence of DFO, 311, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, doxorubicin, and the DpT series of chelators (0-25 μM) for 72 hours at 37°C. The effect of the chelators on proliferation is examined using the MTT assay. |
| Animal Research | CD2F1 mice that are implanted M109 tumors intravenous inject Dp44mT (dissolved in Propylene glycol) 4 mg/kg in twice daily. |
| Molecular Weight | 285.37 |
| Formula | C14H15N5S |
| Cas No. | 152095-12-0 |
| Smiles | CN(C)C(=S)NN=C(c1ccccn1)c1ccccn1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 16.67 mg/mL (58.4 mM), Sonication is recommended.  Ethanol: 47 mg/mL (164.69 mM) H2O: Insoluble | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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