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Dp44mT

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COA HNMR LCMS

Dp44mT

Catalog No. T6821Cas No. 152095-12-0

Dp44mT, a effective iron chelator, has selective antitumor activity.

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Pack Size	Price	Availability
10 mg	$39	In Stock
25 mg	$64	In Stock
50 mg	$113	In Stock
100 mg	$197	In Stock
200 mg	$258	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	Dp44mT, a effective iron chelator, has selective antitumor activity.
In vitro	In MDA-MB-231 cells, Dp44mT selectively targets towards topoisomerase topo2α resulting in DNA damage. Dp44mT inhibits antiproliferative effects significantly with IC50 of 30 nM, 60 nM, and 60 nM for SK-N-MC, SK-Mel-28, and MCF-7 cells, respectively, while showing no effects on normal MRC-5 fibroblasts. In SK-N-MC neuroepithelioma and M109 cells,Dp44mT inhibits cellular Fe uptake from Fe-Tf , and induces cell apoptosis. Dp44mT, as a Pgp substrate, also overcomes multidrug resistance by the hijacking of lysosomal P-glycoprotein (Pgp).
In vivo	Dp44mT (0.4 mg/kg, i.v.) inhibits M109 tumor implanted in CD2F1 mice by a dose-dependent manner.
Cell Research	SK-N-MC, SK-Mel-28, MCF-7 and MRC-5 cells are incubated in the presence and absence of DFO, 311, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, doxorubicin, and the DpT series of chelators (0-25 μM) for 72 hours at 37°C. The effect of the chelators on proliferation is examined using the MTT assay.
Animal Research	CD2F1 mice that are implanted M109 tumors intravenous inject Dp44mT (dissolved in Propylene glycol) 4 mg/kg in twice daily.

Chemical Properties

Molecular Weight	285.37
Formula	C14H15N5S
Cas No.	152095-12-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 16.67 mg/mL (58.4 mM)

Ethanol: 47 mg/mL (164.69 mM)

H2O: Insoluble

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5042 mL	17.5211 mL	35.0422 mL	175.2111 mL
5 mM	0.7008 mL	3.5042 mL	7.0084 mL	35.0422 mL
10 mM	0.3504 mL	1.7521 mL	3.5042 mL	17.5211 mL
20 mM	0.1752 mL	0.8761 mL	1.7521 mL	8.7606 mL
50 mM	0.0701 mL	0.3504 mL	0.7008 mL	3.5042 mL

Ethanol

	1mg	5mg	10mg	50mg
100 mM	0.0350 mL	0.1752 mL	0.3504 mL	1.7521 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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