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Fevipiprant

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Purity:99.32%

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COA HPLC HNMR

Fevipiprant

Catalog No. T3965Cas No. 872365-14-5

Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.

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Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$72	In Stock
25 mg	$147	In Stock
50 mg	$228	In Stock
100 mg	$372	In Stock
200 mg	$549	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Product Introduction

Bioactivity

Description	Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
In vitro	CRTh2-mediated shape change in eosinophils was used to profile QAW039 in whole blood and represents a physiologically relevant environment. The comparable IC50 values for QAW039 in the whole blood and isolated shape-change assays are consistent with its lower plasma-protein binding and its relatively slow dissociation kinetics that drive its increased potency .QAW039 is highly potent in whole-blood systems, with the IC50 value obtained consistent with the affinity values calculated from radioligand experiments. In a further disease-relevant cellular context, the potency of QAW039 in the isolated Th2 cell cytokine inhibition assay is consistent with its CRTh2 receptor affinity, and, as with eosinophil assay readouts, this represents an improved potency compared with QAV680.[
Alias	QAW039, NVP-QAW039

Chemical Properties

Molecular Weight	426.41
Formula	C19H17F3N2O4S
Cas No.	872365-14-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (140.71 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3452 mL	11.7258 mL	23.4516 mL	117.2580 mL
5 mM	0.4690 mL	2.3452 mL	4.6903 mL	23.4516 mL
10 mM	0.2345 mL	1.1726 mL	2.3452 mL	11.7258 mL
20 mM	0.1173 mL	0.5863 mL	1.1726 mL	5.8629 mL
50 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3452 mL
100 mM	0.0235 mL	0.1173 mL	0.2345 mL	1.1726 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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