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Fevipiprant
🥰Excellent
Catalog No. T3965Cas No. 872365-14-5
Alias QAW039, NVP-QAW039
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
Fevipiprant
🥰Excellent
Purity: 99.59%
Catalog No. T3965Alias QAW039, NVP-QAW039Cas No. 872365-14-5
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $29 | In Stock | |
| 10 mg | $43 | In Stock | |
| 25 mg | $88 | In Stock | |
| 50 mg | $137 | In Stock | |
| 100 mg | $223 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:99.59%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist. |
| Targets&IC50 | CRTH2:0.44 nM |
| In vitro | CRTh2-mediated shape change in eosinophils was used to profile QAW039 in whole blood and represents a physiologically relevant environment. The comparable IC50 values for QAW039 in the whole blood and isolated shape-change assays are consistent with its lower plasma-protein binding and its relatively slow dissociation kinetics that drive its increased potency .QAW039 is highly potent in whole-blood systems, with the IC50 value obtained consistent with the affinity values calculated from radioligand experiments. In a further disease-relevant cellular context, the potency of QAW039 in the isolated Th2 cell cytokine inhibition assay is consistent with its CRTh2 receptor affinity, and, as with eosinophil assay readouts, this represents an improved potency compared with QAV680.[ |
| Alias | QAW039, NVP-QAW039 |
| Molecular Weight | 426.41 |
| Formula | C19H17F3N2O4S |
| Cas No. | 872365-14-5 |
| Smiles | Cc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1C(F)(F)F)S(C)(=O)=O |
| Relative Density. | 1.44 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (140.71 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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