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Futibatinib

Futibatinib (FGFR-IN-1) is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.

Catalog No. T5044Cas No. 1448169-71-8

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Purity:99.14%

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COA HPLC HNMR

Futibatinib

Catalog No. T5044Cas No. 1448169-71-8

Futibatinib (FGFR-IN-1) is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$53	In Stock
5 mg	$124	In Stock
10 mg	$182	In Stock
25 mg	$349	In Stock
50 mg	$538	In Stock
100 mg	$697	In Stock
200 mg	$995	In Stock
500 mg	$1,470	In Stock
1 mL x 10 mM (in DMSO)	$136	In Stock

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Product Introduction

Bioactivity

Description	Futibatinib (FGFR-IN-1) is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.
Targets&IC50	FGFR2:1.3 nM (IC50), FGFR2 (V5651):1-3 nM (IC50), FGFR1:3.9 nM (IC50), FGFR2 (WT):0.3 nM (IC50), FGFR3:1.6 nM (IC50), FGFR4:8.3 nM (IC50), FGFR2 (N550H):3.6 nM (IC50), FGFR2 (E566G):2.4 nM (IC50)
In vitro	TAS-120 (3, 30, 100 mg/kg/day, p.o.) exerts an anti-tumor effect in mice. TAS-120 shows anti-tumor effect by administering at moderate intervals, such as intermittent administration of every other day dosing and 2 times/week, and reducing the sustained elevation and weight suppression blood phosphorus level, and take a antitumor effective as daily administration.
Alias	TAS120, FGFR-IN-1

Chemical Properties

Molecular Weight	418.45
Formula	C₂₂H₂₂N₆O₃
Cas No.	1448169-71-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (119.49 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3898 mL	11.9489 mL	23.8977 mL	119.4886 mL
5 mM	0.4780 mL	2.3898 mL	4.7795 mL	23.8977 mL
10 mM	0.2390 mL	1.1949 mL	2.3898 mL	11.9489 mL
20 mM	0.1195 mL	0.5974 mL	1.1949 mL	5.9744 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3898 mL
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1949 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc