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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $116 | In Stock | |
5 mg | $288 | In Stock | |
10 mg | $478 | In Stock | |
25 mg | $789 | In Stock | |
50 mg | $1,080 | In Stock | |
1 mL x 10 mM (in DMSO) | $318 | In Stock |
Description | Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity. |
In vitro | Gimatecan (3 to 300 ng/mL) significantly inhibits the growth of human bladder cancer models (HT1376 and MCR), thus reflecting antiproliferative potency. Gimatecan causes a persistent S-phase arrest At 0.003 µg/mL and the number of S-phase cells increased after treatment with a higher concentration (0.03 µg/mL)[1]. |
In vivo | Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth[1]. |
Alias | LBQ707, STI481 |
Molecular Weight | 447.48 |
Formula | C25H25N3O5 |
Cas No. | 292618-32-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | DMSO: 31.5 mg/mL (70.4 mM) H2O: Insoluble | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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