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IndiMitecan

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Purity:98.25%

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COA HPLC HNMR

IndiMitecan

Catalog No. T60200Cas No. 915360-05-3

IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].

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Pack Size	Price	Availability
1 mg	$116	In Stock
2 mg	$169	In Stock
5 mg	$289	In Stock
10 mg	$442	In Stock
25 mg	$729	In Stock
50 mg	$987	In Stock
100 mg	$1,390	In Stock

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Product Introduction

Bioactivity

Description	IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].
In vitro	Indimitecan (LMP776) exhibits antiproliferative effects across a variety of human cancer cell lines, demonstrating a mean-graph midpoint (MGM) for growth inhibition at 0.079 ± 0.023 μM, as per the National Cancer Institute's developmental therapeutics assay ("NCI60"). Its potent efficacy is highlighted by its ability to induce DNA cleavage through Top1 inhibition and its role as a substrate for metabolic ketone reductases. In specific cell proliferation assays involving cell lines such as HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, and MCF-7, Indimitecan showed growth inhibition with GI50s ranging from <0.01 to 0.08 μM, underscoring its potent antiproliferative activities across a diverse set of cancer cell lines.
Alias	LMP776

Chemical Properties

Molecular Weight	459.45
Formula	C25H21N3O6
Cas No.	915360-05-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 7.7 mg/mL (16.7 mM), when pH is adjusted to 3 with HCl. Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1765 mL	10.8826 mL	21.7652 mL	108.8258 mL
5 mM	0.4353 mL	2.1765 mL	4.3530 mL	21.7652 mL
10 mM	0.2177 mL	1.0883 mL	2.1765 mL	10.8826 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc