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IndiMitecan
🥰Excellent
Catalog No. T60200Cas No. 915360-05-3
Alias LMP776
IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].
IndiMitecan
🥰Excellent
Purity: 98.25%
Catalog No. T60200Alias LMP776Cas No. 915360-05-3
IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $88 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $328 | In Stock | |
| 25 mg | $538 | In Stock | |
| 50 mg | $753 | In Stock | |
| 100 mg | $1,060 | In Stock |
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Purity:98.25%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1]. |
| In vitro | Indimitecan (LMP776) exhibits antiproliferative effects across a variety of human cancer cell lines, demonstrating a mean-graph midpoint (MGM) for growth inhibition at 0.079 ± 0.023 μM, as per the National Cancer Institute's developmental therapeutics assay ("NCI60"). Its potent efficacy is highlighted by its ability to induce DNA cleavage through Top1 inhibition and its role as a substrate for metabolic ketone reductases. In specific cell proliferation assays involving cell lines such as HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, and MCF-7, Indimitecan showed growth inhibition with GI50s ranging from <0.01 to 0.08 μM, underscoring its potent antiproliferative activities across a diverse set of cancer cell lines. |
| Alias | LMP776 |
| Molecular Weight | 459.45 |
| Formula | C25H21N3O6 |
| Cas No. | 915360-05-3 |
| Smiles | COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCn3ccnc3)c(=O)c2cc1OC |
| Relative Density. | 1.48 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 7.7 mg/mL (16.7 mM), when pH is adjusted to 3 with HCl. Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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