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LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $100 | In Stock | |
5 mg | $247 | In Stock | |
10 mg | $372 | In Stock | |
25 mg | $633 | In Stock | |
50 mg | $893 | In Stock | |
100 mg | $1,180 | In Stock |
Description | LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production. |
In vivo | Oral administration of 100 mol x Kg(-1) LASSBio-1135 markedly reduced thermal hyperalgesia induced by carrageenan, however at 10 mol x Kg(-1) only a partial reduction was observed at the 4th h. Neutrophil recruitment and TNF-α production after carrageenan stimulus was also inhibited by the treatment with LASSBio-1135.?Modulating TRPV1 and TNF-α production, two key therapeutic targets of neuropathic pain, 100 mol x Kg(-1) LASSBio-1135 was orally efficacious in reversing thermal hyperalgesia and mechanical allodynia produced by partial sciatic ligation 7-11 days after surgery without provoking hyperthermia, a common side effect of TRPV1 antagonists. |
Molecular Weight | 286.33 |
Formula | C18H14N4 |
Cas No. | 852453-71-5 |
Smiles | N(C1=C(N=C2N1C=CC=C2)C3=CC=CC=N3)C4=CC=CC=C4 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 2.87 mg/mL (10.01 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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