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LP-261

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Purity:99.76%

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COA HNMR HPLC

LP-261

Catalog No. T9595Cas No. 915412-67-8

LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.

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Pack Size	Price	Availability
1 mg	$32	In Stock
2 mg	$45	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$197	In Stock
50 mg	$372	In Stock
100 mg	$556	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock

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Product Introduction

Bioactivity

Description	LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.
Targets&IC50	Tubulin polymerization:3.2 μM (EC50)
In vitro	LP-261 was tested as a single agent in colon adenocarcinoma (SW620) and prostate cancer (LNCaP and PC3) xenografts, evaluating several different dosing schedules. LP-261 was also used in combination with bevacizumab in the SW620 xenograft model. LP-261 also exhibited high oral bioavailability and apparent lack of efflux by intestinal transporters such as ABCB1. LP-261 is a very potent inhibitor of angiogenesis, preventing microvessel outgrowth in the rat aortic ring assay and HUVEC cell proliferation at nanomolar concentrations. Complete inhibition of tumor growth was achieved in the PC3 xenograft model and shown to be schedule dependent. Excellent inhibition of tumor growth in the SW620 model was observed, comparable with paclitaxel[1].
In vivo	LP-261 significantly inhibits growth of a human non-small-cell lung tumor (NCI-H522) in a mouse xenograft model[2].

Chemical Properties

Molecular Weight	421.47
Formula	C22H19N3O4S
Cas No.	915412-67-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 22 mg/ml (52.20 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3726 mL	11.8632 mL	23.7265 mL	118.6324 mL
5 mM	0.4745 mL	2.3726 mL	4.7453 mL	23.7265 mL
10 mM	0.2373 mL	1.1863 mL	2.3726 mL	11.8632 mL
20 mM	0.1186 mL	0.5932 mL	1.1863 mL	5.9316 mL
50 mM	0.0475 mL	0.2373 mL	0.4745 mL	2.3726 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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