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LY2444296

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Catalog No. T11909Cas No. 1346133-11-6
Alias FP3FBZ

LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).

LY2444296

LY2444296

🥰Excellent
Purity: 98.03%
Catalog No. T11909Alias FP3FBZCas No. 1346133-11-6
LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).
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5 mg$39In Stock
10 mg$74In Stock
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Purity:98.03%
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Product Introduction

Bioactivity
Description
LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).
Targets&IC50
κ opioid receptor:ki: ~1 nM
In vivo
LY2444296 reduces anxiety-like and depressive-like behaviors, and CORT release, in rats tested after chronic extended access cocaine self-administration. In cocaine-naïve adult male Sprague Dawley rats, LY2444296 (3 mg/kg; i.p.) prevents behavioral and neuroendocrine effects caused by U69,593[2].
AliasFP3FBZ
Chemical Properties
Molecular Weight408.44
FormulaC24H22F2N2O2
Cas No.1346133-11-6
SmilesNC(=O)c1ccc(Oc2ccc(CN3CCC[C@H]3c3cccc(F)c3)cc2)c(F)c1
Relative Density.1.276 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 25.2 mg/mL (61.7 mM), Sonication is recommended.
Methanol: 5 mg/mL (12.24 mM), Sonication is recommended.
DMSO: 60 mg/mL (146.9 mM)
Solution Preparation Table
Methanol/Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.4483 mL12.2417 mL24.4834 mL122.4170 mL
5 mM0.4897 mL2.4483 mL4.8967 mL24.4834 mL
10 mM0.2448 mL1.2242 mL2.4483 mL12.2417 mL
Ethanol/DMSO
1mg5mg10mg50mg
20 mM0.1224 mL0.6121 mL1.2242 mL6.1209 mL
50 mM0.0490 mL0.2448 mL0.4897 mL2.4483 mL
DMSO
1mg5mg10mg50mg
100 mM0.0245 mL0.1224 mL0.2448 mL1.2242 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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