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LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $39 | In Stock | |
10 mg | $74 | In Stock | |
25 mg | Inquiry | In Stock | |
50 mg | Inquiry | In Stock |
Description | LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM). |
Targets&IC50 | κ opioid receptor:ki: ~1 nM |
In vivo | LY2444296 reduces anxiety-like and depressive-like behaviors, and CORT release, in rats tested after chronic extended access cocaine self-administration. In cocaine-naïve adult male Sprague Dawley rats, LY2444296 (3 mg/kg; i.p.) prevents behavioral and neuroendocrine effects caused by U69,593[2]. |
Alias | FP3FBZ |
Molecular Weight | 408.44 |
Formula | C24H22F2N2O2 |
Cas No. | 1346133-11-6 |
Smiles | NC(=O)c1ccc(Oc2ccc(CN3CCC[C@H]3c3cccc(F)c3)cc2)c(F)c1 |
Relative Density. | 1.276 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 25.2 mg/mL (61.7 mM), Sonication is recommended. Methanol: 5 mg/mL (12.24 mM), Sonication is recommended. DMSO: 60 mg/mL (146.9 mM) | |||||||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||||||||||||
Methanol/Ethanol/DMSO
Ethanol/DMSO
DMSO
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