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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $72 | In Stock | |
5 mg | $178 | In Stock | |
10 mg | $289 | In Stock | |
25 mg | $578 | In Stock | |
50 mg | $833 | In Stock | |
100 mg | $1,150 | In Stock | |
1 mL x 10 mM (in DMSO) | $209 | In Stock |
Description | M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity. |
In vitro | M2698 (0.3 nM-50 M) dose-dependently inhibits proliferation in breast tumor cell lines (IC50s: 0.02-8.5 µM). M2698 (0.3-1 µM) induces feedback loop phosphorylation on Akt and suppresses Akt and p70S6K activity in HCC1419 and MDA-MB-453 cells. M2698 inhibits indirectly pGSK3β and pS6 with IC50s of 17 and 15 nM[1]. |
In vivo | Gavage administration of M2698 (10-30 mg/kg) dose-dependently inhibits the growth of tumors and increases pAkt levels in tumor tissue. M2698 (30 mg/kg) causes tumor regression. M2698 (1-20 mg/kg) inhibits S6 phosphorylation in a dose-proportional manner over time[1]. |
Alias | MSC2363318A |
Molecular Weight | 449.86 |
Formula | C21H19ClF3N5O |
Cas No. | 1379545-95-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 112.5 mg/mL (250.1 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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