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MDR-1339
MDR-1339 (DWK-1339) is an orally active, blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
Catalog No. TQ0026Cas No. 1018946-38-7
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Purity:98.57%
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MDR-1339
Catalog No. TQ0026Alias DWK-1339Cas No. 1018946-38-7
MDR-1339 (DWK-1339) is an orally active, blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $54 | In Stock | |
| 5 mg | $127 | In Stock | |
| 10 mg | $196 | In Stock | |
| 25 mg | $393 | In Stock | |
| 50 mg | $593 | In Stock | |
| 100 mg | $892 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MDR-1339 (DWK-1339) is an orally active, blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation. |
| In vitro | MDR-1339 shows no significant inhibition of a panel of CYP isozymes, while it slightly inhibits CYP2C8 (IC50: 31.4 μM). MDR-1339 (1.5-10 μM) protects cells from this Aβ-induced toxicity. MDR-1339 (3.1-50 μM) also dose-dependently blocks the formation of Aβ aggregates and disaggregates Aβ fibrils. |
| In vivo | MDR-1339 (0.1-10 mg/kg, p.o.) dose-dependently restores passive avoidance responses in Alzheimer's disease mice models (ED50: 0.19 mg/kg) and significantly improves spontaneous alternation while reducing Aβ1-40 and Aβ1-42 levels in APP/PS1 mice at 30 and 100 mg/kg, p.o. daily for 8 weeks. |
| Alias | DWK-1339 |
| Molecular Weight | 326.39 |
| Formula | C20H22O4 |
| Cas No. | 1018946-38-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (122.55 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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