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MF-766 is a highly potent, selective, and orally active EP4 antagonist with a Ki of 0.23 nM, acting as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It is useful for cancer and inflammation diseases research [1][2].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $74 | In Stock | |
5 mg | $178 | In Stock | |
10 mg | $289 | In Stock | |
25 mg | $572 | In Stock | |
50 mg | $822 | In Stock | |
100 mg | $1,130 | In Stock | |
500 mg | $2,280 | In Stock | |
1 mL x 10 mM (in DMSO) | $193 | In Stock |
Description | MF-766 is a highly potent, selective, and orally active EP4 antagonist with a Ki of 0.23 nM, acting as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It is useful for cancer and inflammation diseases research [1][2]. |
Targets&IC50 | EP4:0.23 nM (Ki) |
In vitro | MF-766, at concentrations ranging from 0.01 to 10 μM and pretreated for 1 hour before being stimulated with 50 ng/mL IL-2—both with and without 0.33 μM PGE2 for 18 hours—effectively reverses the suppression of IFN-γ secretion in human NK cells caused by PGE2. Importantly, the viability of NK cells remains unaffected by MF-766[2]. |
In vivo | MF-766 (oral gavage; 30 mg/kg; once daily; 21 days) exhibits TGI% of 49% in CT26 tumor model. But it does not exhibits significant difference in EMT6 and 4T1 tumor model[2]. MF-766 (oral gavage; 30 mg/kg combination with anti-PD-1 mDX400; once daily; 21 days; q4dx8) shows potent anti-tumor activities in different preclinical models. The % of TGI are 89%, 66% and 40%, respectively in CT26 tumor, EMT6 and 4T1 tumor model[2]. |
Molecular Weight | 478.46 |
Formula | C27H21F3N2O3 |
Cas No. | 1050656-06-8 |
Smiles | OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2ccn(Cc3ccc(cc3)C(F)(F)F)c12 |
Relative Density. | 1.36 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (125.4 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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