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MF-766

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COA HNMR HPLC

MF-766

Catalog No. T9622Cas No. 1050656-06-8

MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It can be used for cancer and inflammation diseases research[1][2].

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Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$178	In Stock
10 mg	$289	In Stock
25 mg	$572	In Stock
50 mg	$822	In Stock
100 mg	$1,130	In Stock
500 mg	$2,280	In Stock
1 mL x 10 mM (in DMSO)	$193	In Stock

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Product Introduction

Bioactivity

Description	MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It can be used for cancer and inflammation diseases research[1][2].
In vitro	MF-766, at concentrations ranging from 0.01 to 10 μM and pretreated for 1 hour before being stimulated with 50 ng/mL IL-2—both with and without 0.33 μM PGE2 for 18 hours—effectively reverses the suppression of IFN-γ secretion in human NK cells caused by PGE2. Importantly, the viability of NK cells remains unaffected by MF-766[2].
In vivo	MF-766 (oral gavage; 30 mg/kg; once daily; 21 days) exhibits TGI% of 49% in CT26 tumor model. But it does not exhibits significant difference in EMT6 and 4T1 tumor model[2]. MF-766 (oral gavage; 30 mg/kg combination with anti-PD-1 mDX400; once daily; 21 days; q4dx8) shows potent anti-tumor activities in different preclinical models. The % of TGI are 89%, 66% and 40%, respectively in CT26 tumor, EMT6 and 4T1 tumor model[2].

Chemical Properties

Molecular Weight	478.46
Formula	C27H21F3N2O3
Cas No.	1050656-06-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (125.4 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0900 mL	10.4502 mL	20.9004 mL	104.5019 mL
5 mM	0.4180 mL	2.0900 mL	4.1801 mL	20.9004 mL
10 mM	0.2090 mL	1.0450 mL	2.0900 mL	10.4502 mL
20 mM	0.1045 mL	0.5225 mL	1.0450 mL	5.2251 mL
50 mM	0.0418 mL	0.2090 mL	0.4180 mL	2.0900 mL
100 mM	0.0209 mL	0.1045 mL	0.2090 mL	1.0450 mL

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