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MLN9708

🥰Excellent
Catalog No. T2016Cas No. 1201902-80-8
Alias Ixazomib Citrate

MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazomib Citrate) is MLN2238 in aqueous solutions or plasma.

MLN9708

MLN9708

🥰Excellent
Purity: 98.79%
Catalog No. T2016Alias Ixazomib CitrateCas No. 1201902-80-8
MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazomib Citrate) is MLN2238 in aqueous solutions or plasma.
Pack SizePriceAvailabilityQuantity
5 mg$43In Stock
10 mg$61In Stock
25 mg$97In Stock
50 mg$133In Stock
100 mg$226In Stock
200 mg$336In Stock
500 mg$563In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Purity:98.79%
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Product Introduction

Bioactivity
Description
MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazomib Citrate) is MLN2238 in aqueous solutions or plasma.
Targets&IC50
20S proteasome:0.93 nM(Ki), 20S proteasome:3.4 nM
In vitro
MLN9708 exhibits anticancer activity in a variety of solid tumors and hematologic malignancies.
In vivo
Upon contact with aqueous solutions and plasma, MLN9708 rapidly hydrolyzes into MLN2238, which possesses bioactivity. MLN2238 inhibits the chymotrypsin-like hydrolytic sites of the 20S proteasome ([IC50=3.4 nM,Ki=0.93 nM]). It also inhibits the caspase-like ([IC50=31 nM]) and trypsin-like hydrolytic sites ([IC50=3.5 μM]) of the 20S proteasome.
Kinase Assay
Kinase assay: Calu-6 cells are cultured in MEM containing 10% fetal bovine serum and 1% penicillin/streptomycin and plated 1 day before the start of the experiment at 1 × 104 cells per well in a 384-well plate. Proteasome activity is assessed by monitoring hydrolysis of the chymotrypsin-like substrate Suc-LLVY-aminoluciferin in the presence of luciferase using the Proteasome-Glo assay reagents according to the manufacturer's instructions. Luminescence is measured using a LEADseeker instrument.
Cell Research
Calu-6 cells are cultured in MEM containing 10% FBS and 1% penicillin/streptomycin and plated 1 day before the start of the experiment at 1 × 104 cells per well in a 384-well plate. For IC50 determinations, cells are treated with varying concentrations of Bortezomib or MLN2238 in DMSO (0.5% final, v/v) for 1 hour at 37 °C. For reversibility experiments, cells are treated with either 1 μM Bortezomib or MLN2238 for 30 minutes at 37 °C and then washed thrice in medium to remove the Bortezomib or MLN2238. Cells are incubated for an additional 4 hours at 37 °C, after which the medium is removed and replaced with fresh medium. (Only for Reference)
AliasIxazomib Citrate
Chemical Properties
Molecular Weight517.12
FormulaC20H23BCl2N2O9
Cas No.1201902-80-8
SmilesCC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OC(=O)CC(CC(O)=O)(O1)C(O)=O
Relative Density.1.47 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 93 mg/mL (179.8 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9338 mL9.6689 mL19.3379 mL96.6894 mL
5 mM0.3868 mL1.9338 mL3.8676 mL19.3379 mL
10 mM0.1934 mL0.9669 mL1.9338 mL9.6689 mL
20 mM0.0967 mL0.4834 mL0.9669 mL4.8345 mL
50 mM0.0387 mL0.1934 mL0.3868 mL1.9338 mL
100 mM0.0193 mL0.0967 mL0.1934 mL0.9669 mL

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