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Ixazomib citrate

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Catalog No. T8397Cas No. 1239908-20-3
Alias MLN9708

Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MLN-2238) and an orally bioavailable second-generation proteasome inhibitor with an IC50 of 3.4 nM, exhibiting potential antineoplastic activity.

Ixazomib citrate

Ixazomib citrate

🥰Excellent
Purity: 100%
Catalog No. T8397Alias MLN9708Cas No. 1239908-20-3
Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MLN-2238) and an orally bioavailable second-generation proteasome inhibitor with an IC50 of 3.4 nM, exhibiting potential antineoplastic activity.
Pack SizePriceAvailabilityQuantity
5 mg$43 In Stock
10 mg$61 In Stock
25 mg$93 In Stock
50 mg$126 In Stock
100 mg$207 In Stock
500 mg$515 In Stock
1 mL x 10 mM (in DMSO)$48 In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MLN-2238) and an orally bioavailable second-generation proteasome inhibitor with an IC50 of 3.4 nM, exhibiting potential antineoplastic activity.
Targets&IC50
20S proteasome β5:3.4 nM , 20S proteasome β2:3500 nM, 20S proteasome β1:31 nM
In vitro
Treatment of MM cells with MLN2238 predominantly inhibits chymotrypsin-like activity of the proteasome and induces accumulation of ubiquitinated proteins. MLN2238 inhibits growth and induces apoptosis in MM cells resistant to conventional and bortezomib therapies without affecting the viability of normal cells[1].
In vivo
In animal tumor model studies, Ixazomib is well tolerated and inhibits tumor growth with significantly reduced tumor recurrence. A head-to-head analysis of Ixazomib versus bortezomib showed a significantly longer survival time in mice treated with Ixazomib than mice receiving bortezomib[1].
AliasMLN9708
Chemical Properties
Molecular Weight517.12
FormulaC20H23BCl2N2O9
Cas No.1239908-20-3
SmilesCC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OC(=O)C(CC(O)=O)(CC(O)=O)O1
Relative Density.1.47 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (193.38 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9338 mL9.6689 mL19.3379 mL96.6894 mL
5 mM0.3868 mL1.9338 mL3.8676 mL19.3379 mL
10 mM0.1934 mL0.9669 mL1.9338 mL9.6689 mL
20 mM0.0967 mL0.4834 mL0.9669 mL4.8345 mL
50 mM0.0387 mL0.1934 mL0.3868 mL1.9338 mL
100 mM0.0193 mL0.0967 mL0.1934 mL0.9669 mL

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