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MLS000532223

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Purity:98.11%

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COA HPLC HNMR

MLS000532223

Catalog No. T8473Cas No. 16616-39-0

MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).

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Pack Size	Price	Availability
1 mg	$132	In Stock
2 mg	$193	In Stock
5 mg	$323	In Stock
10 mg	$486	In Stock
25 mg	$795	In Stock
50 mg	$1,090	In Stock
100 mg	$1,490	In Stock
1 mL x 10 mM (in DMSO)	$335	In Stock

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Product Introduction

Bioactivity

Description	MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
In vitro	MLS000532223, a general inhibitor that prevents GTP binding to several GTPases in a dose-dependent manner and is active in biochemical and cell-based secondary assays.?Live-cell imaging and confocal microscopy studies revealed the inhibitor-induced actin reorganization and cell morphology changes, characteristic of Rho GTPases inhibition.

Chemical Properties

Molecular Weight	251.24
Formula	C15H9NO3
Cas No.	16616-39-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (179.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9803 mL	19.9013 mL	39.8026 mL	199.0129 mL
5 mM	0.7961 mL	3.9803 mL	7.9605 mL	39.8026 mL
10 mM	0.3980 mL	1.9901 mL	3.9803 mL	19.9013 mL
20 mM	0.1990 mL	0.9951 mL	1.9901 mL	9.9506 mL
50 mM	0.0796 mL	0.3980 mL	0.7961 mL	3.9803 mL
100 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9901 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc