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Naftopidil hydrochloride
🥰Excellent
Catalog No. T9220Cas No. 1164469-60-6
Alias KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-
Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.
Naftopidil hydrochloride
🥰Excellent
Purity: 99.50%
Catalog No. T9220Alias KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-Cas No. 1164469-60-6
Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $37 | In Stock | |
| 5 mg | $79 | In Stock | |
| 10 mg | $119 | In Stock | |
| 25 mg | $213 | In Stock | |
| 50 mg | $320 | In Stock | |
| 100 mg | $461 | In Stock | |
| 200 mg | $645 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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Purity:99.50%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Naftopidil hydrochloride (BM-15275 hydrochloride) is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects. |
| Targets&IC50 | α1D-adrenoceptor:1.2 nM, α1A-adrenoceptor (human):3.7 nM, α1B-adrenoceptor:20 nM |
| In vitro | Naftopidil hydrochloride reduced the extent of lung fibrosis and SP‐D production in bleomycin‐induced lung fibrosis in mice[1]. |
| In vivo | Naftopidil hydrochloride strongly suppressed cell proliferation of stromal cells, resulting in decreased tumorigenic soluble factor, suggesting that naftopidil might be effective in preventing stromal support of tumor cells[2]. |
| Alias | KT-611 hydrochloride, BM-15275 hydrochloride, 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3- |
| Molecular Weight | 428.95 |
| Formula | C24H29ClN2O3 |
| Cas No. | 1164469-60-6 |
| Smiles | Cl.COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (139.88 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
prostaticprostatepressureNaftopidil hydrochlorideNaftopidil HydrochlorideNaftopidilKT-611 HydrochlorideKT611 HydrochlorideKT-611KT611KT 611 HydrochlorideKT 611InhibitorinhibithyperplasiacanineBM-15275 HydrochlorideBM15275 HydrochlorideBM-15275BM15275BM 15275 HydrochlorideBM 15275Beta ReceptorAdrenergicReceptorAdrenergic Receptor
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