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Naproxen sodium

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Purity:100%

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COA LCMS HNMR

Naproxen sodium

Catalog No. T1582LCas No. 26159-34-2

Naproxen sodium (Anaprox) is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties.

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Pack Size	Price	Availability	Quantity
500 mg	$41	In Stock

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Product Introduction

Bioactivity

Description	Naproxen sodium (Anaprox) is a COX inhibitor for COX-1 and COX-2 with analgesic and antipyretic properties.
In vitro	In rat models of carrageenan-induced arthritis and attenuation of pain perception (IC50=27 μM) as well as yeast-induced fever (IC50=40 μM), Naproxen exhibits inhibitory effects. Additionally, in rats, Naproxen suppresses the production of PGE2 (IC50=12.8 μM) and TXB2 (IC50=5.9 μM) triggered by lipopolysaccharides.
In vivo	In HCA-7 colon cancer cells (IC50=1.45 mM), high concentrations of Naproxen induce apoptosis. Within cells, Naproxen inhibits COX-1 (IC50=2.2 μg/mL) and COX-2 (IC50=1.3 μg/mL).
Kinase Assay	COX-1 and COX-2 activities in intact cells: For the determination of COX-1 and COX-2 inhibition, bovine aortic endothelial cells (BAEC) are incubated for 30 minutes with Naproxen (0.1 ng/mL to 1 mg/mL), and cultured J774.2 macrophages are treated with endotoxin at 1 μg/mL for 12 hours to induce COX-2 followed by incubated for 30 minutes with Naproxen (0.1 ng/mL to 1 mg/mL), respectively. Arachidonic acid (30 μM) is then added, and the cells are incubated for a further 15 minutes at 37 °C. The medium is then removed, and radioimmunoassay is used to measure the formation of 6-keto-PGF1α, PGE2, thromboxane B2, or PGF2α for the assessment of IC50 for COX-1 and COX-2.
Cell Research	Cells are exposed to Naproxen for 24 and 48 hours, respectively. At the end of incubation, cells are harvested by trypsinization, stained with trypan blue solution (0.04% wt/vol) and counted in a Neubauer haemocytometer chamber for the determination of cell viability.(Only for Reference)
Alias	Miranax, Anaprox, RS-3650, Naprelan

Chemical Properties

Molecular Weight	252.24
Formula	C14H13NaO3
Cas No.	26159-34-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.55 mg/mL (18.02 mM)

H2O: 198.2 mM

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9645 mL	19.8224 mL	39.6448 mL	198.2239 mL
5 mM	0.7929 mL	3.9645 mL	7.9290 mL	39.6448 mL
10 mM	0.3964 mL	1.9822 mL	3.9645 mL	19.8224 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.1982 mL	0.9911 mL	1.9822 mL	9.9112 mL
50 mM	0.0793 mL	0.3964 mL	0.7929 mL	3.9645 mL
100 mM	0.0396 mL	0.1982 mL	0.3964 mL	1.9822 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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