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ONO-AE3-208
🥰Excellent
Catalog No. TQ0290Cas No. 402473-54-5
Alias AE 3-208
ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
ONO-AE3-208
🥰Excellent
Purity: 98.27%
Catalog No. TQ0290Alias AE 3-208Cas No. 402473-54-5
ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $58 | In Stock | |
| 10 mg | $93 | In Stock | |
| 25 mg | $159 | In Stock | |
| 50 mg | $235 | In Stock | |
| 100 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $64 | In Stock |
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Purity:98.27%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer. |
| Targets&IC50 | EP3 receptor:30 nM (Ki), FP:790 nM (Ki), EP4:1.3 nM (Ki), TXR:2400 nM (Ki) |
| In vitro | ONO-AE3-208 abolishes CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid causes the dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208 [2]. |
| In vivo | In mice, ONO-AE3-208 significantly reduces bone metastasis of PC3 cells in vivo, as evidenced by reduced photon tumor burdens over time when compared to the control group. Additionally, the rate of metastasis is significantly lower in the ONO-AE3-208-treated group, with a median metastasis formation time of 29 days, compared to 21 days in the control group. |
| Alias | AE 3-208 |
| Molecular Weight | 404.43 |
| Formula | C24H21FN2O3 |
| Cas No. | 402473-54-5 |
| Smiles | CC(C(=O)Nc1cc(ccc1CCCC(O)=O)C#N)c1ccc(F)c2ccccc12 |
| Relative Density. | 1.3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: Insoluble DMSO: 70 mg/mL (173.08 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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