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Results for "
ono-ae3-208
" in TargetMol Product Catalog- Inhibitor Products3
ONO-AE3-208
TQ0290402473-54-5
ONO-AE3-208 (AE 3-208) is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
- $41
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QTY
ONO-AE3-208 sodium
T844442309931-05-1
ONO-AE3-208 is an EP4 receptor antagonist with a Ki of 1.3 nM, exhibiting less potent activity against EP3, FP, and TP receptors (Ki values of 30, 790, and 2,400 nM, respectively), while showing no effect on other prostanoid receptors. In wild type mice, treatment with ONO-AE3-208, in conjunction with 3% dextran sodium sulfate, results in severe colitis characterized by epithelial loss, crypt damage, and inflammation, thereby mimicking the effects of EP4 deletion. Further, this compound has been utilized to investigate the role of EP4 signaling in various biological contexts, including immune and autoimmune responses, inflammation, and cancer.
- Inquiry Price
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ONO-AE-248
T28252211230-67-0
ONO-AE-248 is a selective agonist of EP3 receptor.
- $1,520
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