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Pamidronic acid

Pamidronic acid
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Purity:98%
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Pamidronic acid

Catalog No. T8400Cas No. 40391-99-9
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
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Pack SizePriceAvailabilityQuantity
25 mg$33In Stock
50 mg$50In Stock
100 mg$79In Stock
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Product Introduction

Bioactivity
Description
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
In vitro
Pamidronate disodium inhibited Wnt and β-catenin signaling, which controls osteogenic differentiation in BMMSCs. Wnt3a, a Wnt and β-catenin signaling activator, reversed the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs[1].
Cell Research
Primary human BMMSCs were isolated from the mandible and marrow tissue. A proliferation assay was performed to determine the experimental concentration of pamidronate disodium. Alkaline phosphatase (ALP) activity, ALP staining, and Alizarin red S (ARS) staining were assessed after treatment with pamidronate disodium (0, 0.1, 0.5, 1, 5, 10 μg/mL). Quantitative real-time polymerase chain reaction and western blotting specific for Wnt and β-catenin signaling genes or proteins were performed after treatment with pamidronate disodium 0.5 μg/mL. Wnt3a was used to observe the osteogenic differentiation of BMMSCs during treatment with pamidronate disodium 0.5 μg/mL[1].
Chemical Properties
Molecular Weight235.07
FormulaC3H11NO7P2
Cas No.40391-99-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 6 mg/mL (25.52 mM), Sonication and heating are recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM4.2541 mL21.2703 mL42.5405 mL212.7026 mL
5 mM0.8508 mL4.2541 mL8.5081 mL42.5405 mL
10 mM0.4254 mL2.1270 mL4.2541 mL21.2703 mL
20 mM0.2127 mL1.0635 mL2.1270 mL10.6351 mL

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