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Parecoxib

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Purity:99.90%

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COA HPLC LCMS HNMR

Parecoxib

Catalog No. T1780Cas No. 198470-84-7

Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.

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Pack Size	Price	Availability
10 mg	$30	In Stock
25 mg	$48	In Stock
50 mg	$73	In Stock
100 mg	$123	In Stock
200 mg	$179	In Stock
500 mg	$297	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Product Introduction

Bioactivity

Description	Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.
In vivo	Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH[2].
Alias	SC 69124, Vorth-P, Valus-P

Chemical Properties

Molecular Weight	370.42
Formula	C19H18N2O4S
Cas No.	198470-84-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 2 mg/mL (5.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 50 mg/mL (134.98 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.6996 mL	13.4982 mL	26.9964 mL	134.9819 mL
5 mM	0.5399 mL	2.6996 mL	5.3993 mL	26.9964 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2700 mL	1.3498 mL	2.6996 mL	13.4982 mL
20 mM	0.1350 mL	0.6749 mL	1.3498 mL	6.7491 mL
50 mM	0.0540 mL	0.2700 mL	0.5399 mL	2.6996 mL
100 mM	0.0270 mL	0.1350 mL	0.2700 mL	1.3498 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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