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Pazinaclone
🥰Excellent
Catalog No. T28303Cas No. 103255-66-9
Alias DN-2327, DN2327, DN 2327, A-77000, A77000, A 77000
Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity.
Pazinaclone
🥰Excellent
Purity: 99%
Catalog No. T28303Alias DN-2327, DN2327, DN 2327, A-77000, A77000, A 77000Cas No. 103255-66-9
Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity.
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Purity:99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Pazinaclone is a non-benzodiazepine (GABAA) partial agonist with sedative and anxiolytic activity. |
| In vivo | Pazinaclone (5 mg/kg; oral; rats, mice, hamsters, and guinea pigs) unchanged drug concentration in plasma was highest in mice (AUC; 90 ng/h/ml), followed in decreasing order by guinea pigs (AUC; 41 ng/h/ml), hamsters (AUC; 18 ng/h/ml), and rats (AUC; 17 ng/h/ml). Among rabbits, dogs, and monkeys, the dogs had the highest plasma drug concentrations: AUCs of pazinaclone in dogs and monkeys were 1035 and 458 ng. h/ml, respectively (drug concentration in rabbit plasma was very low). Of the two polymorphs, forms 1 and 2 with particle size of < or = 5 microns, the oral absorption of form 2 in rats was more efficient than that of form 1 at 1000 mg/kg: AUCs of pazinaclone after dosing of form 1 and 2 were 489 and 965 ng.h/ml, respectively.[2] |
| Alias | DN-2327, DN2327, DN 2327, A-77000, A77000, A 77000 |
| Molecular Weight | 478.93 |
| Formula | C25H23ClN4O4 |
| Cas No. | 103255-66-9 |
| Smiles | C(C(=O)N1CCC2(CC1)OCCO2)C3N(C(=O)C=4C3=CC=CC4)C5=NC6=C(C=C5)C=CC(Cl)=N6 |
| Relative Density. | 1.48 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.79 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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