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Peramivir (BCX1812) is a highly selective influenza A and B neuraminidase inhibitor with antiviral activity and anti-cytokine effects, which can be used in the study of novel coronavirus and influenza virus infections.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $64 | In Stock | |
10 mg | $106 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $292 | In Stock | |
100 mg | $433 | In Stock | |
500 mg | $987 | In Stock |
Description | Peramivir (BCX1812) is a highly selective influenza A and B neuraminidase inhibitor with antiviral activity and anti-cytokine effects, which can be used in the study of novel coronavirus and influenza virus infections. |
Targets&IC50 | NA:IC50: 0.9-4.3 nM |
In vitro | Peramivir (2-10 μM, 6-12 h) inhibits LPS-induced cytokine release from hPBMCs[4]. Peramivir (0.3125-40 μM, 4 h) is non-toxic to macrophages[4]. |
In vivo | Peramivir (20-60 mg/kg, intraperitoneal injection, single dose) inhibits LPS-induced cytokine storm, attenuates acute lung injury, and prolongs survival in a mouse model of cytokine storm syndrome [4]. Peramivir (75 mg/kg, intramuscular injection once daily for 7 days) rescued BR/08 lethally attacked BALB scid mice in an immunosuppressed mouse model of influenza B virus infection [5]. |
Alias | RWJ270201, RWJ 270201, BCX1812, BCX 1812 |
Molecular Weight | 328.41 |
Formula | C15H28N4O4 |
Cas No. | 330600-85-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: < 1 mg/mL (insoluble or slightly soluble.) |
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